Research Associate/Senior Research Associate, Oligonucleotide Chemistry

Korro Bio•Cambridge, MA

1d•$70,000 - $110,000•Onsite

About The Position

Korro Bio is seeking a motivated, detail-oriented Research Associate to join its Oligonucleotide Chemistry team. The role involves synthesizing, purifying, and characterizing chemically modified oligonucleotides and conjugates on automated platforms to supply oligonucleotides for screening across Korro’s discovery programs. This hands-on, lab-based position is suited to someone with practical oligonucleotide synthesis experience who takes ownership of instrument operation and maintenance, keeps meticulous records, and communicates results clearly to the team and cross-functionally. The position reports to Scientist II and is based on-site in Cambridge, Massachusetts. Korro Bio is a biopharmaceutical company developing genetic medicines using its proprietary RNA editing platform. Its approach uses the body’s natural RNA editing process to create precise, transient single-base edits, and its lead program targets Urea Cycle Disorders. Korro is based in Cambridge, Massachusetts. The base salary range is $70,000–$110,000 per year. Final salary depends on the level at which the role is filled and factors including skills, competencies, experience, education, and other job-related criteria permitted by law. The range excludes annual bonus and equity. Korro offers equity-based compensation and benefits including medical, dental, and vision coverage; a 401(k) retirement plan; life insurance; dependent care flexible spending account; company-funded health savings account; and complimentary parking or an MBTA commuter pass.

Requirements

BS or MS in Chemistry, Biochemistry, Biotechnology, or a related field, with at least 1 year of experience.
Hands-on experience in the synthesis, purification, and analysis of oligonucleotides.
Strong laboratory skills and experience handling, troubleshooting, and performing routine maintenance on laboratory equipment, including automated synthesis platforms, HPLC, and LC-MS.
Flexibility and self-motivation in a fast-paced work environment.
Excellent organizational skills and ability to prioritize appropriately and meet deadlines.
Excellent interpersonal, communication, and presentation skills.
Detail-oriented with excellent problem-solving abilities.

Nice To Haves

Experience with high-throughput synthesizers such as Mermade 192.

Responsibilities

Execute solid-phase synthesis, purification, and downstream processing of chemically modified oligonucleotides and oligonucleotide conjugates at different scales using modern automated oligonucleotide synthesis platforms.
Operate, maintain, and troubleshoot equipment for oligonucleotide synthesis, purification, desalting, and lyophilization, including Mermade 12 and Mermade 192 instruments.
Cross-train with other synthesis scales and instrumentation.
Maintain inventory of chemicals and amidites for oligonucleotide synthesis.
Perform in-process and final analytics of oligonucleotide samples as needed.
Track, analyze, organize, and present data to the team and cross-functionally.
Maintain a well-documented electronic laboratory notebook.
Participate in training activities and provide training to others as needed.
Author and review SOPs and technical reports.