Oligonucleotide Senior Scientist

Eurofins USA Genomic Services • Louisville, KY

1d

About The Position

Eurofins is seeking a highly skilled, motivated Organic Chemist with expertise in oligonucleotide synthesis and purification to support process development and manufacturing. The role focuses on developing, optimizing, and scaling chemical processes for high-throughput, high-quality oligonucleotide production, including transfer from research and development to manufacturing. The position is full-time, Monday through Friday, 8:00 a.m. to 5:00 p.m., with overtime and weekend work as needed. Candidates living within commuting distance of Louisville, Kentucky, are encouraged to apply.

Requirements

• Ph.D. or master’s degree in Organic Chemistry or a related field.
• At least 5 years of industrial experience in chemical synthesis.
• Hands-on experience with solid-phase oligonucleotide synthesis.
• Hands-on experience in oligonucleotide purification process development.
• Strong analytical skills, including HPLC and LC-MS.
• Experience scaling processes to manufacturing.
• Authorization to work indefinitely in the United States without restriction or sponsorship.
• Ability to manage multiple priorities.

Nice To Haves

• Experience in GMP or regulated environments.
• Familiarity with automated DNA/RNA synthesizers.
• Knowledge of modified nucleotides.
• Experience in high-throughput oligonucleotide production.
• Ability to provide occasional off-hours support.

Responsibilities

• Design, develop, and optimize chemical synthesis processes for nucleotides and oligonucleotides.
• Develop and scale processes from research and development to manufacturing.
• Develop and improve oligonucleotide purification processes, including HPLC, ion-exchange, and desalting.
• Troubleshoot synthesis and purification challenges to improve yield and purity.
• Collaborate with manufacturing, quality control, and engineering teams on process transfer.
• Evaluate new chemistries and technologies.
• Author standard operating procedures, batch records, and technical reports.
• Ensure compliance with quality systems.
• Mentor laboratory technicians.

Benefits

• Comprehensive medical coverage.
• Dental insurance options.
• Vision insurance options.
• Life and disability insurance.
• 401(k) with company match.
• Paid vacation and holidays.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior