Research Associate- Analytical Chemistry

Sapho Bio•San Carlos, CA

2d•$100,000 - $110,000•Onsite

About The Position

Sapho Bio is seeking a meticulous and dependable Research Associate to develop and run HPLC methods for assessing the potency and stability of pharmaceuticals. The role involves working directly with the company’s HPLC instruments and maintaining high standards of laboratory compliance. The ideal candidate is detail-oriented, able to develop methods and independently troubleshoot instrumentation, and motivated by ownership, accountability, and continuous improvement. The position is based at the San Carlos, California office, with consistent on-site attendance Monday through Friday. The role supports strength and stability testing, instrument and consumables management, documentation, and other chemical and biochemical assays as needed. Sapho Bio describes its work as transforming pharmaceutical testing and accelerating access to therapies. Compensation is $100,000–$110,000, commensurate with experience and market benchmarks. Benefits include unlimited PTO, company-recognized holidays, medical, dental, and vision coverage, a 401(k) plan with company matching subject to plan terms, company-paid life insurance, a stock option package, and office meal credits. The company also describes team lunches, office events, and offsite gatherings.

Requirements

MBS/MS in Chemistry, Analytical Chemistry, Biochemistry, Chemical Engineering, Pharmaceutical Sciences, or a related scientific discipline; relevant laboratory experience may be considered in lieu of a degree.
Hands-on experience using HPLC instruments to analyze biologics or small molecules and develop analytical methods.
Independent, motivated, and highly organized, with the ability to manage multiple projects and competing priorities.
Ability to read and comprehend technical documentation, including scientific literature, SOPs, and regulatory documents.
Proficiency with pipetting and general laboratory technique.
Live within a 30-minute commute of San Carlos or be willing to relocate.
Ability to commute consistently to the San Carlos, California office Monday through Friday.

Nice To Haves

Experience using Agilent HPLC instruments for chromatogram acquisition and Agilent OpenLab software for data analysis.
Familiarity with USP, ISO, and/or GLP/GMP standards.

Responsibilities

Develop chromatography-based analytical methods for pharmaceutical strength and stability testing in accordance with USP guidelines; write and review SOPs.
Analyze and interpret data, communicate findings to the laboratory team, and recommend a course of action.
Oversee strength and stability analysis of a variety of compounds and prioritize work to maintain short, efficient turnaround times.
Manage multiple analytical instruments and inventory of standards and consumables; perform regular calibrations and help ensure maximal instrument uptime.
Diagnose and troubleshoot assay and instrumentation problems, and document corrective and preventive actions.
Assist with other chemical and biochemical assays throughout the laboratory as needed.