Principal Scientist I/II, Oligonucleotide Chemistry & Innovation

Novartis•Cambridge, MA

3d•$108,500 - $201,500•Onsite

About The Position

As a Principal Scientist I or II in Oligonucleotide Chemistry and Innovation, you will help build and advance Novartis’ xRNA therapeutic platform. Working with a collaborative team of scientists, you will lead development of novel oligonucleotide chemistries, drive therapeutic innovation, mentor others, and contribute to RNA medicine discovery in a dynamic research environment. The role focuses on advancing potential RNA therapeutic candidates from discovery through preclinical stages.

Requirements

Ph.D. in Chemistry or a related scientific discipline.
At least five years of experience synthesizing therapeutic oligonucleotides in an industry or research setting.
Deep expertise in solid-phase oligonucleotide synthesis, deprotection, purification, and characterization.
Proven experience developing and optimizing novel oligonucleotide chemistries and conjugates.
Strong knowledge of phosphoramidite chemistry and modern synthetic chemistry techniques.
Hands-on experience operating automated oligonucleotide synthesizers and analytical instrumentation.
Demonstrated understanding of RNA therapeutics, including small interfering RNA and antisense oligonucleotides.
Excellent collaboration and communication skills, with the ability to work across multidisciplinary teams.

Responsibilities

Lead synthesis, purification, characterization, and analysis of chemically modified oligonucleotides and conjugates.
Design and optimize novel oligonucleotide chemistries through structure-activity relationship studies.
Develop and implement robust synthetic routes for preclinical RNA therapeutic candidates.
Collaborate across functions to advance oligonucleotide therapeutic programs from discovery through preclinical stages.
Mentor scientists and improve laboratory workflows for efficiency, quality, and innovation.
Establish and maintain standard operating procedures that support reproducible oligonucleotide manufacturing processes.
Operate, troubleshoot, and maintain analytical and synthesis instrumentation, including high performance liquid chromatography and liquid chromatography mass spectrometry.