Postdoctoral Research Fellow
About The Position
The Mass General Brigham Department of Anesthesiology at Massachusetts General Hospital is hiring two Postdoctoral Research Fellows to conduct basic research into the function, mechanisms, and translational applications of tRNA-derived small RNAs (tDRs) and RNA pseudouridylation in heart disease, chronic kidney disease, and Alzheimer's disease. The fellows will work with supervision and guidance while carrying out specialized research, analyzing and communicating results, and contributing to manuscripts and grant applications. Assistance guiding research technicians and trainees is expected. The role has a secondary appointment at Harvard Medical School. One opening focuses on molecular and RNA biology; the other focuses on in vivo and surgical research. Applicants should be organized, detail-oriented, communicative, and able to work both independently and collaboratively. This is a courtesy posting. Applicants should email a CV and cover letter to Dr. Guoping Li at [email protected] rather than apply through Workday.
Requirements
- PhD or MD in molecular biology, biochemistry, cell biology, genetics, physiology, pharmacology, biomedical engineering, neuroscience, or a related field.
- Prior laboratory research experience.
- At least one first-author peer-reviewed SCI publication demonstrating scientific productivity.
- Ability to work independently under the general direction of the Principal Investigator and collaboratively with lab members.
- Strong organizational, meticulousness, and detail-orientation.
- Initiative and enthusiasm for learning new techniques.
- Strong analytical and problem-solving skills.
- Strong technical abilities and computer science skills.
- Exceptional written and oral communication skills, demonstrated by publications and presentations.
- Ability to make independent and effective decisions in a timely fashion.
- Competence in research techniques and methodologies.
- Excellent interpersonal skills and ability to work well with other lab members.
Nice To Haves
- For the molecular/RNA biology position: a solid background in molecular and cell biology and proficiency in standard molecular techniques.
- For the molecular/RNA biology position: experience with non-coding RNA.
- For the molecular/RNA biology position: familiarity with next-generation sequencing library preparation or bioinformatic analysis, including RNA-seq or small RNA-seq.
- For the molecular/RNA biology position: experience with gene editing, including CRISPR/Cas, and primary-cell or iPSC culture.
- For the in vivo/surgical position: hands-on in vivo experience, particularly microsurgical skills in rodent models of cardiac or kidney disease.
- For the in vivo/surgical position: experience with models such as myocardial infarction, transverse aortic constriction, ischemia-reperfusion injury, renal ischemia-reperfusion, unilateral ureteral obstruction, or 5/6 nephrectomy.
- For the in vivo/surgical position: experience with drug administration, including tail-vein, intrapericardial, renal-capsular, and local delivery.
- For the in vivo/surgical position: experience with echocardiography or cardiac/renal functional assessment, and tissue harvesting and phenotyping.
Responsibilities
- Perform independent and highly specialized experimental procedures.
- Design and implement modifications to research protocols.
- Troubleshoot problems and instruct colleagues in highly specialized techniques.
- Synthesize and interpret research results.
- Record and analyze data using software programs and statistical techniques.
- Maintain organized and detailed records of laboratory experiments in electronic laboratory notebooks.
- Present results at lab meetings and national conferences.
- Prepare and submit research manuscripts to peer-reviewed journals.
- Assist with preparation of grant applications.
- Assist in guiding research technicians and trainees in the lab.
- Perform other duties as assigned.
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What This Job Offers
Job Type
Full-time
Career Level
Entry Level
Education Level
Ph.D. or professional degree
