Postdoctoral Research Fellow

Mass General Brigham • Boston, MA

1d • Onsite

About The Position

The Mass General Brigham Department of Anesthesiology at Massachusetts General Hospital is seeking two Postdoctoral Research Fellows to conduct basic research into the function, mechanisms, and translational applications of tRNA-derived small RNAs (tDRs) and RNA pseudouridylation in heart disease, chronic kidney disease, and Alzheimer's disease. The fellows will bring complementary expertise in molecular/RNA biology or in vivo/surgical research. The role requires organizational skills, attention to detail, effective communication, and the ability to work both independently and as part of a team. The secondary appointment will be at Harvard Medical School.

With supervision and guidance, fellows will conduct specialized experiments, adapt and troubleshoot research protocols, analyze and interpret data, maintain detailed electronic laboratory records, present findings, prepare manuscripts, and assist with grant applications. Assistance guiding research technicians and trainees is expected.

The position is onsite at 55 Fruit Street. The compensation range is $71,750–$81,179, with the specific range influenced by experience and organizational guidelines. Applications should be emailed with a CV and cover letter to Dr. Guoping Li; applications submitted only through Workday may not be forwarded.

Requirements

• PhD or MD in molecular biology, biochemistry, cell biology, genetics, physiology, pharmacology, biomedical engineering, neuroscience, or a related field.
• Prior laboratory research experience.
• Evidence of strong scientific productivity, including at least one first-author peer-reviewed SCI publication.
• Ability to work independently under the general direction of the Principal Investigator.
• Motivation, meticulousness, organization, and attention to detail.
• Initiative and enthusiasm for learning new techniques.
• Strong analytical and problem-solving skills.
• Strong technical abilities and computer science skills.
• Exceptional written and oral communication skills, demonstrated through publications and presentations.
• Ability to make independent and effective decisions in a timely fashion.
• Competence in research techniques and methodologies.
• Excellent interpersonal skills and ability to work well with other laboratory members.

Nice To Haves

• For the Molecular/RNA Biology position: a solid background in molecular and cell biology and proficiency in standard molecular techniques.
• Experience with non-coding RNA.
• Familiarity with next-generation sequencing (RNA-seq/small RNA-seq) library preparation or bioinformatic analysis.
• Experience with gene editing (CRISPR/Cas).
• Experience with primary-cell or iPSC culture.
• For the In Vivo/Surgical position: hands-on in vivo experience, particularly microsurgical skills in rodent models of cardiac or kidney disease.
• Experience with rodent cardiac disease models such as myocardial infarction, transverse aortic constriction (TAC), or ischemia-reperfusion injury.
• Experience with rodent kidney disease models such as renal ischemia-reperfusion, unilateral ureteral obstruction (UUO), or 5/6 nephrectomy.
• Experience with drug administration, including tail-vein, intrapericardial, renal-capsular, and local delivery.
• Experience with echocardiography or cardiac/renal functional assessment, and tissue harvesting and phenotyping.

Responsibilities

• Perform independent and highly specialized experimental procedures.
• Design and implement modifications to research protocols.
• Troubleshoot problems and instruct colleagues in specialized techniques.
• Synthesize and interpret results.
• Record and analyze data using software programs and statistical techniques.
• Maintain organized, detailed laboratory experiment records in electronic laboratory notebooks.
• Present results at laboratory meetings and national conferences.
• Prepare and submit research manuscripts to peer-reviewed journals.
• Assist with preparation of grant applications.
• Assist in guiding research technicians and trainees in the laboratory.
• Perform other duties as assigned.

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree