Postdoctoral Research Associate - Epidemiology and Cancer Control

St. Jude Children's Research Hospital • Memphis, TN

34d

About The Position

The Department of Epidemiology and Cancer Control seeks a highly motivated postdoctoral researcher to join Dr. Yadav Sapkota’s laboratory. The grant-funded role focuses on the pharmacogenomics of long-term toxicities of cancer therapy in childhood cancer survivors. Research topics include genetic association analyses of long-term health outcomes among survivors of European and African ancestries; multi-omics and systems genetics analyses to investigate molecular mechanisms underlying health outcomes; and evaluating health disparities through pharmacogenomics.

The researcher will have opportunities to work with large-scale whole-genome and whole-exome sequencing, RNA-seq, ATAC-seq, proteomics, and metabolomics data from a well-established childhood cancer survivor cohort with clinically ascertained, deeply phenotyped health outcomes at multiple time points. The role is part of a diverse, collaborative, multidisciplinary research environment and offers training and experience in genetic epidemiology, pharmacogenomics, and computational and analytical methods, with access to shared core facilities, resources, and cutting-edge tools and technologies. Grant-writing training and support are also available.

Requirements

• PhD or equivalent degree in genetics, epidemiology, biostatistics, bioinformatics, or a related quantitative field.
• Strong publication record.
• Strong research interests in genetic epidemiology, pharmacogenomics, statistical genetics, or population genetics.
• Experience in statistical and computational analyses of high-throughput omics data.
• Ability to code in one or more scientific programming languages, such as R, Python, or C/C++.
• Excellent communication and writing skills.

Responsibilities

• Conduct genetic association analyses, including whole-genome and whole-exome sequence association analyses and polygenic risk score analyses, for long-term health outcomes among childhood cancer survivors of European and African ancestries.
• Analyze multi-omics data, including genomics, transcriptomics, proteomics, and metabolomics, and systems genetics data to investigate molecular mechanisms underlying health outcomes.
• Study eQTLs that regulate molecular responses to cancer therapies in human induced pluripotent stem cells.
• Evaluate health disparities through pharmacogenomics.
• Work with large-scale sequencing and other omics data from a childhood cancer survivor cohort with deeply phenotyped outcomes.
• Participate in a collaborative, multidisciplinary research environment and develop computational, analytical, and grant-writing skills.

Benefits

• Competitive salary
• Excellent benefits
• Access to shared core facilities and resources
• Grant-writing training and support

What This Job Offers

• Job Type: Full-time
• Career Level: Intern
• Education Level: Ph.D. or professional degree