Postdoctoral Fellow, Protein Sciences, Kschonsak Lab

Roche • South San Francisco, CA

1d • $100,000 - $106,500 • Onsite

About The Position

A Postdoctoral Fellow position is available for a highly motivated and independent candidate to join the laboratory of Dr. Marc Kschonsak in the Protein Engineering and Structural Biology Group within the Protein Sciences Department at Genentech. In this role, you will answer fundamental questions in membrane protein biology, focusing on the structural and functional mechanisms of transmembrane proteins, and their associated macromolecular signaling complexes. The Kschonsak Lab works on the biochemical and structural mechanisms of novel membrane proteins and their larger, endogenous signaling assemblies. We leverage a highly multidisciplinary approach—combining cryo-EM, endogenous purifications, and functional reconstitution—to understand how these complex systems operate across both recombinant and endogenous contexts. In this role, you will have access to state-of-the-art structural biology and biophysical equipment and facilities. In addition, you will have opportunities to collaborate with other labs both within Genentech and in academia, and present your work at conferences.

Requirements

• Ph.D. in a Relevant Field with a proven track record of creativity, rigor, and success in structural biology, biochemistry, biophysics, or a related field, as exemplified by first-author publication(s) in high-impact journals.
• Experience with expression and purification of challenging proteins.
• Experience with single-particle cryo-EM and/or X-ray crystallography sample preparation, data collection, and processing.
• Independent and capable of designing, executing, and troubleshooting complex biochemistry and structural biology workflows to answer challenging biological questions.
• Strong collaborative spirit to work with others in a team to bring projects to fruition.
• Strong oral and written communication skills.

Nice To Haves

• Successful experience with the expression and purification of membrane proteins.
• Successful experience with the reconstitution of membrane proteins into lipid environments (e.g., liposomes, nanodiscs) and establishing functional transport or signaling assays.
• Experience in isolating endogenous complexes from tissues or cell lines.
• Experience with mammalian cell culture, heterologous expression, or cellular functional assays.

Responsibilities

• Answer fundamental questions in membrane protein biology, focusing on the structural and functional mechanisms of transmembrane proteins, and their associated macromolecular signaling complexes.
• Leverage a highly multidisciplinary approach—combining cryo-EM, endogenous purifications, and functional reconstitution—to understand how these complex systems operate across both recombinant and endogenous contexts.
• Collaborate with other labs both within Genentech and in academia.
• Present your work at conferences.

Benefits

• Competitive salaries
• Fully funded research expenses
• Access to world-class seminars
• Professional development workshops
• Networking opportunities
• Relocation benefits

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree