Cohen Lab- Postdoctoral Fellow

University of Colorado • Aurora, CO

2d • $63,480 - $77,076 • Onsite

About The Position

The Cohen Lab at CU Anschutz (NIH/DoD/DARPA-funded) seeks a postdoctoral fellow supported by the NIH T32 Critical Injury and Illness Training Program. The R01-funded project centers on the protein C pathway as the mechanistic bridge between trauma-induced coagulopathy (TIC) and thromboinflammation. Work uses human trauma biorepository samples, validated mouse models of hemorrhagic shock, a 3D endothelial flow model, and high-throughput proteomics, metabolomics, and lipidomics. Projects include therapeutic modulation of APC activity via nanobodies and engineered variants, endothelial barrier and calcium signaling assays, and multiomic phenotyping of post-injury states. Candidates should hold a PhD in biochemistry, molecular biology, cell biology, or bioengineering with experience in endothelial cell models, microfluidic/flow systems, rodent models, and/or multiomics. Strong interest in translational research at the intersection of coagulation, inflammation, and therapeutics is required.

Requirements

• PhD in biochemistry, molecular biology, cell biology, bioengineering, or a closely related field.
• Experience in endothelial cell models, microfluidic/flow systems, rodent models, and/or multiomics.
• Strong interest in translational research at the intersection of coagulation, inflammation, and therapeutics.
• Legally authorized to work in the United States without requiring sponsorship.

Nice To Haves

• Biochemistry: protein biochemistry, enzyme kinetics, coagulation assays, recombinant protein expression
• Molecular biology: gene expression analysis, RiboTag/RNA-seq, CRISPR, cloning
• Cell biology: endothelial cell culture, barrier function assays, calcium imaging, confocal microscopy
• Bioengineering & flow models: microfluidic systems, 3D flow chamber assays, hemodynamic modeling
• Animal models: in vivo mouse models of trauma, hemorrhagic shock, or critical illness
• Multiomics: proteomics, metabolomics, lipidomics, or bioinformatic data analysis

Responsibilities

• Contribute to ongoing R01-funded aims focused on: (1) mechanistic characterization of protein C pathway activation in trauma-induced coagulopathy using clinical patient samples and ex vivo mixing studies with APC-selective nanobodies and engineered superFVa;
• (2) endothelial biology of thromboinflammation including barrier function, calcium signaling, and mitochondrial metabolic dysfunction studied in a novel 3D flow model and validated mouse models of hemorrhagic shock;
• and (3) multiomic (proteomic, metabolomic, lipidomic) endotyping of post-injury phenotypes and trajectories using a biorepository of >10,000 samples from severely injured patients.
• Be co-mentored by Dr. Mitchell J. Cohen MD FACS (trauma surgeon-scientist, Professor of Surgery, Bruce Rockwell Chair) and a multidisciplinary team including experts in coagulation biology, proteomics/metabolomics, thrombosis modeling, and bioengineering.
• Participate in structured training in grant writing, scientific communication, and career development through the NIH T32 Critical Injury and Illness Training Program.
• Utilize state-of-the-art core facilities at CU Anschutz including mass spectrometry, flow cytometry, high-resolution microscopy, and a dedicated Level 1 Trauma Center biorepository.

Benefits

• Comprehensive benefits package
• Generous leave
• Health plans
• Retirement contributions

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree