Cohen Lab- Postdoctoral Fellow

University of Colorado • Aurora, CO

14h • Onsite

About The Position

The Cohen Lab at CU Anschutz is seeking a postdoctoral fellow supported by the NIH T32 Critical Injury and Illness Training Program. This NIH/DoD/DARPA-funded lab studies trauma-induced coagulopathy and thromboinflammation, focusing on the protein C system biology, endothelial dysfunction, and novel therapeutics. The R01-funded project investigates the protein C pathway as the mechanistic link between trauma-induced coagulopathy (TIC) and thromboinflammation. The research utilizes human trauma biorepository samples, validated mouse models of hemorrhagic shock, a 3D endothelial flow model, and high-throughput proteomics, metabolomics, and lipidomics. Projects include therapeutic modulation of APC activity via nanobodies and engineered variants, endothelial barrier and calcium signaling assays, and multiomic phenotyping of post-injury states. The fellow will be co-mentored by Dr. Mitchell J. Cohen and a multidisciplinary team, with structured training in grant writing, scientific communication, and career development provided by the NIH T32 program. Access to state-of-the-art core facilities and a dedicated Level 1 Trauma Center biorepository is available.

Requirements

• PhD in biochemistry, molecular biology, cell biology, bioengineering, or a closely related field.
• Experience in endothelial cell models.
• Experience in microfluidic/flow systems.
• Experience in rodent models.
• Experience in multiomics.
• Strong interest in translational research at the intersection of coagulation, inflammation, and therapeutics.
• Applicants must be legally authorized to work in the United States without requiring sponsorship.

Nice To Haves

• Protein biochemistry
• Enzyme kinetics
• Coagulation assays
• Recombinant protein expression
• Gene expression analysis
• RiboTag/RNA-seq
• CRISPR
• Cloning
• Endothelial cell culture
• Barrier function assays
• Calcium imaging
• Confocal microscopy
• Microfluidic systems
• 3D flow chamber assays
• Hemodynamic modeling
• In vivo mouse models of trauma, hemorrhagic shock, or critical illness
• Proteomics
• Metabolomics
• Lipidomics
• Bioinformatic data analysis

Responsibilities

• Contribute to ongoing R01-funded aims focused on mechanistic characterization of protein C pathway activation in trauma-induced coagulopathy using clinical patient samples and ex vivo mixing studies with APC-selective nanobodies and engineered superFVa.
• Investigate the endothelial biology of thromboinflammation, including barrier function, calcium signaling, and mitochondrial metabolic dysfunction, using a novel 3D flow model and validated mouse models of hemorrhagic shock.
• Perform multiomic (proteomic, metabolomic, lipidomic) endotyping of post-injury phenotypes and trajectories using a biorepository of over 10,000 samples from severely injured patients.
• Participate in structured training in grant writing, scientific communication, and career development.
• Utilize state-of-the-art core facilities at CU Anschutz, including mass spectrometry, flow cytometry, and high-resolution microscopy.

Benefits

• Comprehensive benefits package
• Generous leave
• Health plans
• Retirement contributions

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree