Postdoctoral Fellow-MSH-32035-054
About The Position
The Postdoctoral Fellow will join the Diabetes, Obesity and Metabolism Institute laboratory studying pancreatic beta-cell biology, including beta-cell failure, adaptive expansion, and stress resilience in metabolic disease. The project examines transcription factor dynamics, including the ChREBP axis, and cytoprotective mechanisms. The fellow will investigate early drivers of beta-cell failure and evaluate therapeutic small-molecule 14-3-3 molecular glues, such as Compound 43, designed to protect beta-cells from glucolipotoxicity and cytokine stress. The research aims to clarify pathways that mediate beta-cell failure and validate interventions that preserve beta-cell mass and function. The fellow is expected to drive the project toward high-impact peer-reviewed publications, present findings at national and international conferences, and contribute to grant applications. The work is based at 1428 Madison Ave, Atran Building, 5th floor.
Requirements
- Ph.D., M.D./Ph.D., or equivalent degree in Molecular Biology, Biochemistry, Biomedical Sciences, or a closely related discipline.
- Strong, demonstrable background in molecular biology and biochemistry.
- Mandatory hands-on experience in mouse handling and in vivo protocols.
Nice To Haves
- Prior expertise in pancreatic islet biology is highly preferred.
- Experience with NGS sequencing and analysis is optional.
Responsibilities
- Lead studies of early drivers of pancreatic beta-cell failure.
- Evaluate therapeutic small-molecule 14-3-3 molecular glues, including Compound 43, for protecting beta-cells from glucolipotoxicity and cytokine stress.
- Perform hands-on mouse handling and in vivo protocols.
- Conduct core molecular biology and biochemistry protocols and confocal imaging.
- Drive the research project toward high-impact peer-reviewed publications.
- Present research at national and international conferences, such as ADA Scientific Sessions or HIRN meetings.
- Contribute to grant applications.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
