Postdoctoral Associate | Bennett Lab

The Jackson Laboratory • Bar Harbor, ME

2d • $65,589 - $75,569 • Onsite

About The Position

The Bennett Lab is dedicated to uncovering the fundamental mechanisms that govern the developmental emergence of hematopoietic stem cells (HSCs) and translating these insights toward improved stem cell engineering for regenerative medicine. The laboratory focuses on understanding HSC specification and maturation in embryonic development by: 1) defining how TGF-β/BMP signaling regulate the transition from pre-HSCs to transplantable HSCs, including the role of SMAD7 and related downstream effectors. 2) the identification of novel regulators to this process and defining how rare pre-hematopoietic stem cell intermediates arise from hemogenic endothelium and mature into fully functional, multi-lineage engraftable HSCs. Our long-term goal is to identify the precise molecular signals that enable robust HSC formation and use this knowledge to improve the efficiency of producing of transplantable HSCs for therapeutic purposes. The Bennett lab uses a multidisciplinary approach integrating mouse genetics, embryo models, transplantation assays, flow cytometry, confocal microscopy, clonal barcoding, and single-cell genomics. The lab offers a highly collaborative environment with opportunities to work across programs at The Jackson Laboratory as well as with external collaborators in the field. Trainees will be supported in fellowship applications, publications, conference presentations, and career development toward academic or industry paths.

Requirements

• Ph.D., M.D., or equivalent degree in biological sciences or related discipline
• Minimum of one first-author publication from graduate studies or prior postdoctoral work
• Strong foundational training in molecular biology, cell biology, developmental biology, or stem cell biology
• Excellent verbal and written communication skills
• Self-motivated and able to work independently as well as collaboratively

Nice To Haves

• Hematopoiesis, stem cell biology, developmental biology, or vascular biology
• Mouse models, transplantation assays, or in vivo lineage tracing
• Flow cytometry, cell sorting, and primary cell culture
• Single-cell RNA-seq, ATAC-seq, spatial genomics, or related genomic technologies
• Lentiviral systems or clonal barcoding
• Computational biology, bioinformatics, or quantitative data analysis

Responsibilities

• Plan, develop, execute, and analyze an independent research project within the lab’s main focus areas. Potential projects may include mechanistic studies into how TGFb/BMP signaling pathways regulates pre-HSC maturation or mapping transcriptional states of developmental HSC emergence using single-cell and clonal barcoding approaches.
• Prepare manuscripts, fellowship applications, and conference presentations.
• Mentor junior lab members.
• Contribute to a collaborative team environment.

Benefits

• Fellowship applications support
• Publication support
• Conference presentation support
• Career development support toward academic or industry paths

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree