Postdoctoral Associate - Hwang Lab

Broad Institute • Cambridge, MA

21h

About The Position

The Hwang laboratory at the Broad Institute of MIT & Harvard is seeking a highly motivated postdoctoral associate to investigate host genetic factors involved in human papillomavirus (HPV)-driven cellular immortalization and transformation. The project focuses on understanding and ultimately inhibiting HPV-driven carcinogenesis, whose key drivers are the HPV E6 and E7 oncoproteins. Following genome-scale CRISPRi and CRISPRa screens in primary human cells, the work is advancing to validation and mechanistic characterization of screen hits.

The successful candidate will lead hit validation and downstream mechanistic studies, complete ongoing sub-pool screens, and drive resulting manuscripts, with opportunities to develop independent follow-up directions. The position calls for effective collaboration across multiple institutions, strong communication, and a commitment to basic and translational research. Training and expertise in virology and functional genomics are essential; the role is particularly suited to researchers interested in host-pathogen interactions and virus-induced cancers.

Requirements

• PhD in virology, microbiology, genetics, immunology, or a closely related field.
• Record of successfully leading projects through publication in scientific journals and presentation at scientific conferences.
• Solid understanding of and hands-on experience in functional genomics, including CRISPR screens (CRISPRi/CRISPRa), molecular cloning, lentivirus production, and next-generation sequencing.
• Experience with virology assays and handling and modulating primary human cells in the presence and absence of infection.
• Training and expertise in virology and functional genomics.
• Excellent oral and written communication, wet-lab, organization, and time-management skills.
• High initiative and motivation, with the ability to work independently and as part of a team.
• Strong desire to learn new methods and ability to think creatively to solve problems.

Nice To Haves

• Bioinformatic analysis of screen and sequencing data.

Responsibilities

• Work independently and with team members to design and carry out experiments essential to the individual project and the group's collective success.
• Lead validation and mechanistic characterization of hits from CRISPRi/CRISPRa screens.
• Complete ongoing sub-pool screens.
• Consult the literature, supervisor, and other scientific staff as needed to troubleshoot experiments.
• Investigate, learn, and develop methods and technologies relevant to the project.
• Maintain and share detailed experimental records, documentation, and written protocols with team members.
• Contribute to grants, papers, and patents.

Benefits

• Medical, dental, vision, life, and disability insurance.
• 401(k) retirement plan.
• Flexible spending and health savings accounts.
• At least 13 paid holidays.
• Winter closure.
• Paid time off.
• Parental and family care leave.
• Employee assistance program.

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree