Post Doctoral Scholar- Microbial Infection and Immunity

The Ohio State University • Columbus, OH

1d • Onsite

About The Position

The research project is centered on the metabolic reprogramming that regulates tumor-infiltrating myeloid cells and their interplay with T cells in mouse model and in humans. The Post Doctoral Researcher will pursue specialized research training and experience under the guidance of a scientific mentor; conducts research to characterize the immunologic and genetic basis of human cancers; develops, adopts and implements new experimental methods to achieve further characterization of various human immune cell types, their respective developmental pathways; delineates mechanisms of tumor resistance to immunotherapy, such as immune checkpoint inhibitors (ICI), identifies novel genes and examines their role in the development of immunologic approaches to disease treatment; analyzes changes in mRNA or protein expression, flow cytometric analysis, gene cloning and mutation detection; integrate cutting edge single-cell RNA sequencing and multi-parametric flow cytometry with traditional molecular biology based approaches; participates in analyzing data for reports for the purpose of grants submissions; designs and conducts pre-clinical studies using a variety of disease models in mice; trains staff, focuses efforts to generate a better understanding of resistance to ICI, to conceive and develop novel treatments/combinations and biomarkers, identify new targets for novel therapeutics, use multi-color flow cytometry, cell isolation and primary cell and tissue culture.

Requirements

• A Doctoral degree in an appropriate discipline is required.
• Previous experience working with research animals (mice).
• Previous experience with DNA/RNA/Protein isolation, purification.
• Previous experience with PCR/qPCR, Western blot techniques.
• Previous experience with molecular cloning.
• Previous experience with mammalian cell culture.
• Previous experience with flow cytometric data collection and analysis.

Nice To Haves

• Experience with high dimensional data analysis (e.g. single-cell RNA-Seq) is highly desirable.
• Previous experience training others in molecular biology techniques such as cloning, real time PCR, complex data analyses.

Responsibilities

• Pursue specialized research training and experience under the guidance of a scientific mentor.
• Conduct research to characterize the immunologic and genetic basis of human cancers.
• Develop, adopt and implement new experimental methods to achieve further characterization of various human immune cell types and their respective developmental pathways.
• Delineate mechanisms of tumor resistance to immunotherapy, such as immune checkpoint inhibitors (ICI).
• Identify novel genes and examine their role in the development of immunologic approaches to disease treatment.
• Analyze changes in mRNA or protein expression, flow cytometric analysis, gene cloning and mutation detection.
• Integrate cutting edge single-cell RNA sequencing and multi-parametric flow cytometry with traditional molecular biology based approaches.
• Participate in analyzing data for reports for the purpose of grants submissions.
• Design and conduct pre-clinical studies using a variety of disease models in mice.
• Train staff.
• Focus efforts to generate a better understanding of resistance to ICI.
• Conceive and develop novel treatments/combinations and biomarkers.
• Identify new targets for novel therapeutics.
• Use multi-color flow cytometry, cell isolation and primary cell and tissue culture.

Benefits

• Competitive salary
• Outstanding benefits
• Participation in workshops and conferences
• High quality Shared Resources
• Many opportunities for continued professional development
• Medical, dental and vision coverage, with Ohio State paying a significant portion of the cost.
• Paid time off, including sick and vacation time and 11 holidays.
• State retirement plan or an alternative retirement plan, both with generous employer contributions.

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree