Post Doc - Open Rank - Wolfe Lab

University of Massachusetts Medical School • Worcester, MA

1d • Onsite

About The Position

The Wolfe laboratory is seeking a postdoctoral researcher to develop therapeutic genome editing reagents for muscular dystrophies and cancer. This role involves developing prime editing reagents for precise correction of Limb Girdle Muscular Dystrophy mutations, creating genome editing reagents for selective cancer cell killing, utilizing unbiased genome-wide techniques to assess off-target events, and translating these reagents to clinical application through in vivo safety and efficacy studies in mouse models. The position offers exposure to cutting-edge genome editor engineering, in vivo reagent delivery via lipid nanoparticles, and deep-sequencing approaches for evaluating off-target editing. The successful candidate will also have opportunities to participate in meetings and conferences related to genome editing and gene therapy.

Requirements

• Ph.D. in biology, biochemistry, chemistry or a related biomedical science.
• Strong oral and written communication skills.
• Eagerness to present research results at national meetings.

Nice To Haves

• Prior experience with genome editing systems.
• Prior experience with cell culture.
• Prior experience with deep-sequencing technologies.
• Prior experience with mouse disease models.

Responsibilities

• Develop therapeutic genome editing reagents for muscular dystrophies and cancer.
• Develop prime editing reagents with high activity and specificity for precise correction of common pathogenic mutations associated with Limb Girdle Muscular Dystrophy.
• Develop genome editing reagents for selective killing of cancer cells harboring gene amplifications.
• Utilize unbiased genome-wide techniques for assessing off-target events and other genomic alterations potentially associated with genome editing.
• Translate developed genome editing reagents to clinical application through in vivo safety and efficacy studies in relevant mouse models.
• Learn cutting-edge deep-sequencing approaches to evaluate off-target editing within the genome.
• Participate in meetings/conferences associated with genome editing and gene therapy.

Benefits

• Equal opportunity employer
• Affirmative action employer

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree