Organic and Conjugation Chemist

Amgen • Thousand Oaks, CA

3d • Hybrid

About The Position

The Hybrid Modality Group at Amgen is seeking a highly motivated scientist in the field of Antibody Drug Conjugates (ADC) to join us in the state-of-the-art research facility at the Amgen headquarters campus located in Thousand Oaks, CA. The qualified candidate will work at the interface of synthetic chemistry, biochemistry, and chemical biology, and apply their chemical synthesis skills in developing new antibody drug conjugates to support the advancement of drug discovery programs.

Requirements

• Master's Degree Or Bachelor's Degree and 2+ years of relevant experience OR Associate’s degree and 4 years of relevant experience OR High school diploma / GED and 6 years of relevant experience
• Experienced in organic synthesis including executing and optimizing chemical reactions
• Basic understanding of purification and analytical methods
• Eagerness to learn chemical conjugation and characterization of ADC
• Demonstration of good lab practices, with particular attention to safety
• Strong written and verbal communication skills
• Ability to work comfortably within a dynamic team of scientists and engineers with diverse technical and cultural backgrounds

Responsibilities

• Perform multistep organic synthesis of linker-payload reagents under supervision
• Purify and characterize small molecules using techniques such as flash chromatography, HPLC, LC/MS, and NMR.
• Learn and perform bioconjugation of antibodies, peptides, and small molecule payloads and characterize conjugates using analytical techniques, such as HPLC, LC-MS, and SEC
• Document experimental plans and procedures in electronic lab notebooks while following appropriate SOPs.
• Generate, analyze and summarize scientific data and provide regular updates on project results.
• Operate and maintain standard lab equipment

Benefits

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Associate degree