ADC Development: Organic and Conjugation Chemist

Amgen • Thousand Oaks, CA

2d • Hybrid

About The Position

The hybrid Modality Group in the Protein Engineering Department at Amgen is seeking a highly motivated organic chemist to join us in the state-of-the-art research facility at the Amgen headquarters campus located in Thousand Oaks, CA. The qualified candidate will work at the interface of synthetic chemistry, biochemistry, and chemical biology to apply their synthetic skills in developing ADC therapeutics and cutting-edge novel modalities.

Requirements

• Doctorate degree specializing in organic chemistry, biochemistry, chemical biology, medicinal chemistry OR Master’s degree and 3 years of laboratory experience OR Bachelor’s degree and 5 years of laboratory experience
• Demonstration of good lab practices, with particular attention to safety
• Strong written and verbal communication skills
• Ability to work comfortably within a large team of scientists and engineers with diverse technical and cultural backgrounds.

Nice To Haves

• Postdoc or 2 years of synthetic chemistry experience preferred.
• Experience in the synthesis and purification of ADC linker and payloads.
• Experience in bioconjugation process is preferred.
• Experience with peptide synthesis and purification is preferred.
• A robust understanding of structural determination using NMR and MS techniques and proficient with a range of chromatography methods (e.g. HPLC, RP HPLC, ion exchange, size exclusion chromatography)

Responsibilities

• Design, synthesis, purification and characterization of novel organic linkers, peptides, and payloads for antibody drug conjugates.
• Design, synthesis, purification, and characterization of antibody drug conjugates for therapeutic discovery.
• Review, analyze, and interpret scientific data and results; provide regular updates, documentation, and/or communication on project results.

Benefits

• Full support and career-development resources to expand your skills, enhance your expertise, and maximize your potential along your career journey.
• A diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree