Oligonucleotide Senior Scientist

Eurofins•Louisville, KY

49d•Onsite

About The Position

We are seeking a highly skilled and motivated Organic Chemist with expertise in oligonucleotide synthesis and purification to support process development and manufacturing. This role focuses on developing, optimizing, and scaling chemical processes for high-throughput and high-quality oligonucleotide production.

Requirements

Ph.D. or Master’s degree in Organic Chemistry or related field (required)
Minimum 5 years of industrial experience in chemical synthesis
Hands-on experience with solid-phase oligonucleotide synthesis
Hands-on experience in oligonucleotide purification process development
Strong analytical skills (HPLC, LC-MS)
Experience scaling processes to manufacturing
Authorization to work in the United States indefinitely without restriction or sponsorship.

Nice To Haves

Experience in GMP or regulated environments, preferred
Familiarity with automated DNA/RNA synthesizers, strongly preferred
Knowledge of modified nucleotides, strongly preferred
Experience in high-throughput oligo production, strongly preferred
Fast-paced, collaborative environment
Ability to manage multiple priorities
Occasional off-hours support as needed

Responsibilities

Design, develop, and optimize chemical synthesis processes for nucleotides and oligonucleotides
Process development and scale-up from R&D to manufacturing
Develop and improve oligonucleotide purification processes (e.g., HPLC, ion-exchange, desalting)
Troubleshoot synthesis and purification challenges to improve yield and purity
Collaborate with manufacturing, QC, and engineering for process transfer
Evaluate new chemistries and technologies
Author SOPs, batch records, and technical reports
Ensure compliance with quality systems
Mentor lab technicians