Manager, Clinical Supply Chain - Operations
About The Position
We are seeking an individual for the role of Manager – Clinical Supply Chain, Operations. In this position, you will play a pivotal role in ensuring reliable, compliant execution of clinical supply across programs, supporting Alnylam’s growing pipeline and patient needs. Your focus will be on overseeing end-to-end clinical supply execution activities across assigned protocols, ensuring timely delivery of materials to sites and patients. You will partner closely with cross-functional teams including Clinical Operations, Quality Assurance, Regulatory Affairs, and external vendors to execute clinical trials effectively. Overall, you will be accountable for ensuring uninterrupted supply, managing operational risks, and delivering execution excellence across protocols in a dynamic environment. This position is hybrid and will be primarily located in the Alnylam Cambridge office.
Requirements
- B.Sc. in a scientific field or Supply Chain Management or related field
- 5+ years of direct Clinical Supply Chain experience globally
- Demonstrated knowledge of clinical supply chain packaging, labeling, inventory management, global distribution
- Strong understanding of clinical trial operations and drug development lifecycle
- Foundational knowledge of GMP / GxP / GCP and global regulatory requirements (FDA, EU, etc.)
- Experience with systems/tools (IRT/IXRS, inventory systems, Excel, Smartsheet, ERP)
- Risk identification, assessment, and mitigation
- Project management across multiple studies/programs
- Vendor / CMO / CRO management and oversight
- Budget tracking, cost control, and financial oversight of protocols
- Problem-solving and risk-based decision making
- Proficient knowledge of MS Office (Excel, PowerPoint, Visio, Project, etc)
- Excellent communication, attention to detail, collaboration, ability to manage complex challenges, and influencing skills
Responsibilities
- Responsible for end-to-end execution of clinical supply activities including IRT, packaging, labeling, distribution, inventory management, returns, destruction, and study closeout
- Ensure protocol milestones are met on time and in full (e.g., FPI, SIV readiness, on-time delivery to sites/patients)
- Partner cross-functionally with Clinical Operations, QA, Regulatory, and CMOs to ensure efficient and compliant execution
- Manage and escalate day-to-day execution risks including delays, deviations, and supply disruptions with clear escalation and mitigation
- Oversee temperature excursions and supply deviations ensuring appropriate documentation and resolution
- Ensure execution activities are compliant, well-documented, and inspection-ready
- Maintain visibility to inventory levels and supply availability across programs
- Contribute to continuous improvement of execution processes, tools, and ways of working
- Train fellow trial leads
Benefits
- medical, dental, and vision coverage
- life and disability insurance
- a lifestyle reimbursement program
- flexible spending and health savings accounts
- a 401(k)with a generous company match
- paid time off
- wellness days
- holidays
- two company-wide recharge breaks
- generous family resources and leave
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What This Job Offers
Job Type
Full-time
Career Level
Manager
