Local Study Operations Line Sr. Manager

Amgen • Thousand Oaks, CA

3d • $151,988 - $205,630

About The Position

The Local Study Operations Line Sr. Manager leads the skill development of Local Study Operations Managers (LSOMs), ensuring effective country-level trial implementation and alignment with global strategies. The role oversees delivery of the country study portfolio, including scope, timelines, and budgets, through LSOM leadership. In partnership with the Country GSSO Head, the position supports an optimal clinical research environment aligned with global R&D objectives and drives consistent execution through best practices, digital innovation, knowledge sharing, and continuous improvement.

Requirements

• Doctorate degree and 2 years of clinical execution experience; or master’s degree and 6 years; or bachelor’s degree and 8 years; or associate’s degree and 10 years; or high school diploma/GED and 12 years.
• At least 2 years of experience directly managing people and/or leadership experience leading teams, projects, or programs, or directing resource allocation. This experience may run concurrently with the required technical experience.

Nice To Haves

• 7 years of work experience in a life sciences or medically related field, including 4 years of biopharmaceutical clinical research experience working on clinical trials at a biotech, pharmaceutical, or CRO company.
• Experience managing multiple teams or direct reports across multiple clinical functions or trials.
• Experience at or overseeing clinical research vendors, such as CROs, central labs, or imaging vendors.
• Experience managing clinical operations across a relevant geography or region, including strong understanding of local regulatory requirements for global clinical trials.

Responsibilities

• Ensure successful delivery of the study portfolio assigned to LSOMs.
• Oversee LSOM responsibilities across the assigned country portfolio, from feasibility through study close-out.
• Monitor portfolio progress, provide risk and quality oversight, and support issue escalation and resolution.
• Manage LSOM and LSOM vendor performance, serve as the primary escalation point for local study challenges, drive solutions, and ensure portfolio targets are met.
• Mentor, train, and support the professional development of LSOMs.
• Build and maintain a high-performing team.
• Facilitate collaboration between the study strategy team and local study teams.
• Promote cross-functional collaboration among country teams to deliver the country portfolio.
• Support study placement discussions based on country capabilities and growth potential.
• Evaluate risks, quality trends, and resource requirements; implement mitigation strategies and drive continuous improvement in country operations.
• Lead initiatives to improve operational efficiency and encourage sharing of best practices.
• Manage resource allocation and workload distribution across LSOMs, including FSP and FTE personnel, to optimize trial execution and align with global priorities.
• Ensure adherence to applicable regulatory and quality standards.
• Collaborate with and support the country head in engaging cross-functional stakeholders, aligning on trial deliverables, and managing escalations.

Benefits

• Retirement and Savings Plan with company contributions
• Group medical coverage
• Dental coverage
• Vision coverage
• Life insurance
• Disability insurance
• Flexible spending accounts
• Discretionary annual bonus program (or sales-based incentive plan for field sales representatives)
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible
• Career development opportunities

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: High school or GED