LBA Automation Scientist II

AbbVie•Worcester, MA

3d•$84,500 - $162,000•Onsite

About The Position

The LBA Operations lab within Quantitative Translational & ADME Sciences (QTAS) in Worcester, Massachusetts, seeks an experienced automation scientist to support pre-clinical bioanalytical programs in a non-regulated, fast-paced environment. The role involves bioanalysis of animal samples dosed with large-molecule therapeutics, including pharmacokinetic (PK), toxicokinetic (TK), pharmacodynamic (PD), and anti-drug-antibody (ADA) studies using manual and automated Meso Scale Discovery (MSD) assay protocols. It also involves designing and optimizing automation protocols for ligand-binding assay (LBA) workflows on Tecan and Hamilton liquid handlers. The Scientist I/II develops and executes bioanalytical strategies for PK, PD, TK, and ADA studies using automated liquid-handling systems. This lab-based role covers assay design, planning, data interpretation, and applying automation expertise to expand analytical capabilities supporting oncology, immunology, and neuroscience portfolios. The role calls for a strong background in bioanalysis, biochemistry, chemistry, or a related field, along with bioanalytical assay automation experience. The position is onsite at the AbbVie Bioresearch Center in Worcester, Massachusetts.

Requirements

Bachelor’s degree in biochemistry, chemistry, or pharmacology and 7 or more years of industry experience, or a master’s degree or equivalent and 5 or more years of experience.
Experience conducting PK/PD/TK bioanalysis on antibodies, bi-/multi-specifics, and/or antibody-drug conjugates (ADCs), including data interpretation.
Experience with assay development and troubleshooting using ligand-binding workflows such as ELISA and MSD.
Automation experience.
Strong attention to detail and problem-solving skills; ability to work as a motivated, reliable, independent contributor and team player.
Excellent written and verbal communication skills.
Proficiency with computers and data-analysis software, including LIMS systems.
Ability to design, summarize, communicate, and interpret bioanalytical results.
Ability to collaborate effectively in a highly matrixed environment.

Responsibilities

Design and execute pre-clinical rodent and non-human primate bioanalytical studies using newly developed or existing protocols and manual or automated LBA protocols on Hamilton and Tecan instruments.
Serve as the lab’s automation subject matter expert and establish automated assay strategies for large-molecule bioanalysis.
Communicate assay plans, timelines, results, and data interpretations clearly with study teams and QTAS stakeholders.
Train and mentor junior scientists on LBA protocols using automation.
Archive data in ELN and LIMS systems.
Write and update experimental protocols and procedures.
Independently initiate, design, interpret, and troubleshoot operational assays efficiently.