Executive Director, U.S. Medical Affairs Cardiovascular Portfolio Lead

Amgen • Thousand Oaks, CA

47d • $325,302 - $440,114 • Hybrid

About The Position

Join Amgen’s Mission of Serving Patients. At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Requirements

• Doctorate degree & 6 years of medical affairs/cardiovascular experience OR Master’s degree & 10 years of medical affairs/cardiovascular experience OR Bachelor’s degree & 12 years of medical affairs/cardiovascular experience AND 6 years of managerial experience directly managing people and/or leadership experience leading teams, projects, programs or directing the allocation of resources
• In-depth experience developing and executing U.S. Medical Affairs strategies across a portfolio or multiple assets, preferably within cardiovascular disease
• Experience translating clinical development and evidence-generation strategy into integrated U.S. cardiovascular portfolio and asset-level medical priorities
• MD or other advanced clinical or scientific degree
• Experience with both inline and pipeline launches in the U.S.
• 10+ years of biopharmaceutical industry experience across Medical Affairs, Clinical Development, or related functions
• Demonstrated experience leading U.S. product launches, lifecycle management, and portfolio strategy
• Broad scientific and clinical knowledge across cardiovascular disease, including atherosclerotic cardiovascular disease and lipid management
• Strong knowledge of U.S. evidence generation, scientific communication, congress planning, field medical strategy, and external engagement
• Experience developing above-brand disease-state strategies and applying implementation science approaches to close evidence-to-practice gaps across healthcare systems
• Experience leading across multiple assets, indications, or cardiovascular disease areas and establishing portfolio-level priorities and synergies
• Demonstrated ability to collaborate effectively with adjacent medical teams, including Obesity Medical, on shared scientific and patient-care priorities
• Experience partnering with U.S. professional societies, advocacy organizations, academic institutions, health systems, payers, and other external cardiovascular stakeholders
• Experience translating global strategies into integrated U.S. portfolio and asset plans
• Expertise in medical education, insight generation, and stakeholder engagement within applicable legal, regulatory, and compliance requirements
• Strong financial, budgeting, governance, prioritization, and resource management capabilities
• Experience building and developing high-performing Medical Affairs and/or Field Medical teams
• Strong strategic thinking, executive communication, change leadership, and matrix leadership skills
• Experience leveraging digital and AI-enabled solutions to improve medical engagement and operational effectiveness
• Deep understanding of the U.S. healthcare environment, clinical guidelines, reimbursement, access, quality measures, population health, and policy landscape
• Knowledge of Good Clinical Practice, U.S. regulatory requirements, and Medical Affairs compliance standards

Responsibilities

• Serve on the U.S. Medical Affairs leadership team to shape enterprise and cardiovascular strategic priorities.
• Lead the development and execution of an integrated U.S. medical strategy across established and pipeline cardiovascular assets, including atherosclerotic cardiovascular disease, dyslipidemia, and related cardiovascular priorities.
• Maintain strong strategic and executional leadership for Repatha while building a coherent portfolio approach for future cardiovascular programs.
• Translate global asset and disease-area strategies into differentiated U.S. priorities based on clinical practice, guidelines, policy, access, health-system, and patient needs.
• Identify portfolio-level and above-brand synergies across implementation science, evidence generation, scientific platforms, stakeholder engagement, medical education, congresses, field deployment, and operational capabilities.
• Partner with U.S. Field Medical, Implementation Science, Clinical Development, Commercial, Access, Regulatory, Legal, Compliance, and Global Medical Affairs to align scientific and medical objectives across the cardiovascular portfolio.
• Lead development of an above-brand cardiovascular strategy across the U.S. Medical Affairs team to address shared disease-state priorities, prevention, diagnosis, guideline implementation, care pathways, health equity, and system-level barriers beyond individual assets.
• Collaborate with Implementation Science colleagues to identify barriers and facilitators to evidence-based cardiovascular care; design, test, evaluate, sustain, and scale interventions; and translate findings into portfolio strategy, field execution, and health-system partnerships.
• Work in close collaboration with the Obesity Medical team on shared scientific priorities, evidence-generation opportunities, field insights, education, and external engagement at the intersection of obesity and cardiovascular risk, while maintaining clear portfolio ownership and governance.
• Lead and develop U.S. Medical Affairs team members to drive excellence in evidence generation, scientific communication, medical education, congress planning, and stakeholder engagement.
• Oversee an integrated U.S. congress and professional society strategy across cardiology, lipidology, primary care, and other relevant cardiovascular specialties, with coordinated engagement alongside the Obesity Medical team when appropriate.
• Drive differentiated U.S. scientific narratives, core medical content, publications, educational initiatives, and external engagement plans at both the portfolio and asset levels.
• Engage experts, professional societies, advocacy organizations, integrated delivery networks, health systems, payers, quality organizations, and academic networks to strengthen scientific partnerships and address cardiovascular care gaps.
• Support independent medical education and other compliant educational initiatives for physicians, nurses, pharmacists, advanced practice professionals, and patient-focused stakeholders.
• Partner with Field Medical leadership to establish portfolio and asset-level engagement priorities, strengthen MSL capabilities, and convert field insights into actionable medical strategy.
• Ensure compliant capture, synthesis, communication, and use of scientific insights across cardiovascular diseases, assets, field interactions, congresses, advisory activities, and external partnerships.
• Lead U.S. launch readiness and lifecycle management for marketed and pipeline cardiovascular assets, including sequencing priorities and balancing resources across the portfolio.
• Provide medical input into U.S. access, reimbursement, quality improvement, policy, prevention, and value-based partnership priorities across cardiovascular disease.
• Advance evidence generation—including clinical, real-world, health economics, implementation science, population health, and outcomes research—to address U.S. cardiovascular evidence gaps, accelerate translation of evidence into practice, and demonstrate portfolio impact.
• Promote integrated, multidisciplinary approaches to cardiovascular risk reduction and coordinate with the Obesity Medical team on areas of shared patient need.
• Lead resource planning, prioritization, governance, and budget allocation across U.S. Medical Affairs cardiovascular portfolio objectives.
• Drive innovation and operational excellence, including responsible use of AI-enabled solutions across insight generation, medical engagement, congress planning, stakeholder management, and operations.
• Recruit, develop, and mentor a high-performing U.S. Medical Affairs team while fostering a collaborative, inclusive, and patient-focused culture.
• Strengthen Amgen’s reputation as a trusted, science-driven, patient-focused partner within the U.S. cardiovascular community.

Benefits

• Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans and bi-annual company-wide shutdowns
• Flexible work models where possible.

What This Job Offers

• Job Type: Full-time
• Career Level: Executive
• Education Level: Ph.D. or professional degree