Executive Director, Portfolio Systems & Strategy Integration

Revolution Medicines•Redwood City, CA

1d•Hybrid

About The Position

Revolution Medicines is seeking a leader to own and evolve its Portfolio Systems and Intelligence capability as the company advances a growing oncology pipeline and faces important decisions about program advancement, resource allocation, and competitive positioning. The role ensures leaders have integrated data, insights, tools, and decision infrastructure to assess portfolio health, evaluate strategic trade-offs, and make high-quality portfolio decisions. Initially reporting to the SVP, Head of Program, Lifecycle, and Portfolio Strategy (PLPS), the Executive Director will be both a systems integrator and a strategic thought partner. The role partners closely with Information Technology to translate portfolio business requirements into scalable technology, data, and integration solutions. It also leads cross-portfolio analyses and strategy initiatives, strengthens connections between portfolio-level decisions and functional plans, and supports senior leadership and Board-level discussions with rigorous, integrated portfolio insights. This is a builder’s role for someone who can develop systems and capabilities while delivering practical outcomes. The position also helps maintain the operating model for Portfolio & Pipeline Strategy and identifies and implements improvements to portfolio management processes, capabilities, and tools.

Requirements

10+ years of experience in portfolio management, strategy, or a related function within a biotechnology or pharmaceutical company, with increasing scope and responsibility.
Direct experience with portfolio governance, including supporting portfolio review committees, decision tracking, and cross-functional coordination at the program level.
Strong systems thinking and data fluency, including the ability to design or improve portfolio tracking tools and dashboards, work with structured data, and produce clear, decision-ready outputs from complex information.
Demonstrated ability to manage complex, multi-stakeholder projects with minimal supervision, balancing rigor with pragmatism and speed.
Excellent communication and executive presence, including the ability to prepare and present materials for senior leadership, simplify complex topics, and build credibility with diverse stakeholders.
Strong operational savvy and organizational awareness, including the ability to navigate ambiguity and competing priorities in a matrixed organization.
Experience and proficiency with modeling on portfolio management platforms.

Nice To Haves

Experience with oncology drug development.
Familiarity with clinical-stage pipeline operations and program decision-making.
Advanced degree (MBA, MS, or PhD).
Prior experience in a chief of staff, strategy, or business operations role at a clinical-stage biotech.
Experience building or significantly improving a portfolio management function, including its systems, processes, and team capabilities.

Responsibilities

Own and evolve the Portfolio Systems strategy and roadmap, including evaluating, selecting, designing, implementing, driving adoption of, and optimizing portfolio platforms, data infrastructure, dashboards, and decision-support tools.
Build and lead an integrated intelligence capability by synthesizing input from Clinical, Regulatory, CMC, Commercialization, and Finance into coherent views of portfolio health, risks, opportunities, dependencies, and strategic trade-offs.
Ensure leadership has appropriate information at the right time, especially for key decision gates and governance forums.
Partner with Information Technology to translate portfolio business requirements into scalable technology and integration solutions.
Lead and coordinate cross-portfolio strategy projects, including portfolio prioritization analyses, scenario planning, pipeline reviews, and resource-allocation analyses.
Independently scope complex analyses and strategic initiatives, integrate cross-functional perspectives, and translate findings into clear recommendations for portfolio leadership.
Drive integration between Portfolio & Pipeline Strategy and the broader organization by establishing information flows, standards, and cross-functional ways of working.
Surface emerging risks, issues, dependencies, and opportunities, and support alignment between portfolio-level decisions and functional plans.
Serve as a senior strategic advisor to the Head of Portfolio & Pipeline Strategy, independently leading priority Portfolio Systems and Intelligence workstreams and framing complex issues and recommendations.
Ensure senior leadership and Board-level discussions are supported by rigorous, integrated portfolio insights.
Help build and maintain the Portfolio & Pipeline Strategy operating model, including team rhythms, communication cadences, meeting structures, and onboarding for team members and governance participants.
Identify opportunities to improve portfolio management, including process improvements, capability gaps, and tool investments; develop actionable proposals and lead their implementation.
Model Revolution Medicines’ values and contribute to a high-performance team culture focused on intellectual rigor, collaborative problem-solving, and patients.