Executive Director, Portfolio Systems & Strategy Integration

Revolution Medicines•Redwood City, CA

13h•$265,000 - $331,000

About The Position

Revolution Medicines is seeking a Senior/Executive Director, Portfolio Systems & Strategy Integration to own and evolve its Portfolio Systems and Intelligence capability. Initially reporting to the SVP, Head of Program, Lifecycle, and Portfolio Strategy (PLPS), this person will ensure leaders have integrated data, insights, tools, and decision infrastructure to understand portfolio health, evaluate strategic trade-offs, and make high-quality portfolio decisions. The role serves as both a systems integrator and a strategic thought partner to the Head of PLPS, and partners closely with Information Technology to convert portfolio business requirements into scalable technology, data, and integration solutions. The position will lead portfolio systems strategy and roadmap development, build an integrated intelligence capability from cross-functional inputs, and independently scope and lead complex cross-portfolio analyses and strategic initiatives. It will strengthen information flows and ways of working between Portfolio & Pipeline Strategy and the broader organization, support senior leadership and Board-level discussions with integrated portfolio insights, and help develop the operating model for the function. The role also identifies and implements improvements to portfolio-management processes, capabilities, and tools. Revolution Medicines is a global oncology company focused on discovering, developing, and delivering medicines for patients with RAS-addicted cancers. The company describes its culture as grounded in following the science, challenging assumptions, acting with urgency, and maintaining rigor in service of patients. The position is full-time; the listed base salary range for candidates working onsite at the Redwood City, California headquarters is $265,000–$331,000, subject to adjustment for local market and individual factors.

Requirements

At least 10 years of experience in portfolio management, strategy, or a related function within a biotechnology or pharmaceutical company, with increasing scope and responsibility.
Direct experience with portfolio governance, including supporting portfolio review committees, decision tracking, and cross-functional coordination at the program level.
Strong systems thinking and data fluency, including ability to design or improve portfolio tracking tools and dashboards, work with structured data, and translate complex information into decision-ready outputs.
Demonstrated ability to manage complex, multi-stakeholder projects with minimal supervision while balancing rigor, pragmatism, and speed.
Excellent communication and executive presence, including ability to prepare and present materials for senior leadership, simplify complex topics, and build credibility with diverse stakeholders.
Operational savvy and organizational awareness, including understanding how to navigate a matrixed organization, ambiguity, and competing priorities.
Experience and proficiency with modeling on portfolio management platforms.

Nice To Haves

Experience with oncology drug development; familiarity with clinical-stage pipeline operations and program decision-making is a significant asset.
Advanced degree (MBA, MS, or PhD).
Prior experience in a chief of staff, strategy, or business operations role at a clinical-stage biotech.
Experience building or significantly improving a portfolio management function, including its systems, processes, and team capabilities.

Responsibilities

Own and evolve the Portfolio Systems strategy and roadmap, including evaluating, selecting, designing, implementing, adopting, and optimizing platforms, data infrastructure, dashboards, and decision-support tools.
Build and lead an integrated intelligence capability by synthesizing inputs from Clinical, Regulatory, CMC, Commercialization, and Finance into coherent views of portfolio health, risks, opportunities, dependencies, and strategic trade-offs.
Ensure leaders receive decision-ready information at the right time, especially for decision gates and governance forums.
Partner with Information Technology to translate portfolio business requirements into scalable technology and integration solutions.
Lead and coordinate cross-portfolio strategy projects, including prioritization analyses, scenario planning, pipeline reviews, and resource-allocation analyses.
Independently scope complex work, integrate cross-functional perspectives, and translate findings into clear recommendations for portfolio leadership.
Drive integration between Portfolio & Pipeline Strategy and the broader organization by establishing information flows, standards, and cross-functional ways of working.
Surface emerging risks, issues, dependencies, and opportunities, and support alignment between portfolio-level decisions and functional plans.
Serve as a senior strategic advisor to the Head of Portfolio & Pipeline Strategy, leading priority Portfolio Systems and Intelligence workstreams and framing complex issues and recommendations.
Support senior leadership and Board-level discussions with rigorous, integrated portfolio insights.
Help build and maintain the operating model for Portfolio & Pipeline Strategy, including team rhythms, communication cadences, meeting structures, and onboarding for team members and governance participants.
Identify opportunities to improve portfolio management, including process improvements, capability gaps, and tool investments; develop proposals and lead implementation.
Model company values and contribute to a high-performance culture characterized by intellectual rigor, collaborative problem-solving, and commitment to patients.