Executive Director, GCS Kidney — POVE

Vertex Inc. • Boston, MA

3d • $260,600 - $390,800 • Hybrid

About The Position

The Executive Director, Global Commercial Strategy (GCS) Kidney will be the senior commercial leader for povetacicept across kidney indications, including immunoglobulin A nephropathy (IgAN) and primary membranous nephropathy (pMN). The role owns the global commercial strategy for the kidney franchise, supporting the near-term U.S. launch and subsequent global launches in IgAN while advancing pMN toward commercialization.

The Executive Director will co-lead the povetacicept Kidney Program Team with the Development Lead, guiding program strategy and key development, lifecycle, and investment decisions. The role leads global launch execution and lifecycle management in IgAN and builds the global commercialization and launch strategy for pMN. The position also builds and leads a high-performing kidney commercial team and partners across functional and regional teams to deliver a globally aligned strategy and launch plan.

Requirements

• Bachelor’s degree in business, marketing, life sciences, healthcare, or a related field.
• Extensive biopharmaceutical commercial experience, including global commercial strategy, new product planning, or marketing leadership.
• Demonstrated experience leading global launch strategy and execution for specialty or rare disease products.
• Strong experience in lifecycle management, commercial development, forecasting, evidence strategy, and investment decision-making.
• Launch or development experience in nephrology, specialty, rare disease, immunology, or other complex markets.
• Exceptional strategic thinking, analytical rigor, business judgment, communication, and influencing skills.
• Proven people leadership and ability to build collaborative, high-performing teams.

Nice To Haves

• Advanced degree such as an MBA, M.S., Pharm.D., Ph.D., or M.D.
• Direct kidney experience strongly preferred.
• Program-team leadership experience preferred.

Responsibilities

• Co-lead the povetacicept Kidney Program Team with the Development Lead, setting integrated strategy, priorities, and decision frameworks across IgAN and pMN.
• Own global commercial strategy for povetacicept in kidney, connecting launch, lifecycle, development, evidence, and investment priorities across the franchise.
• Lead GCS support for the U.S. IgAN launch and subsequent global launches, ensuring strategy, success factors, regional alignment, readiness, and execution.
• Own global lifecycle management for povetacicept in IgAN, advancing opportunities to strengthen differentiation, expand patient impact, generate evidence, and maximize long-term value.
• Lead the global commercialization and launch strategy for pMN, including market development, positioning, target product profile, evidence needs, value proposition, launch sequencing, and readiness.
• Shape development plans and lead commercial development activities across IgAN and pMN, including market research, forecasting, competitive intelligence, scenario planning, evidence requirements, and business cases.
• Build understanding of IgAN and pMN markets, patients, treatment pathways, competition, access dynamics, and success requirements.
• Align the kidney strategy with the broader povetacicept portfolio, partnering with GCS leaders for non-kidney indications while maintaining accountability by vertical.
• Partner with Development, Medical, Regulatory, Value & Access, Finance, Manufacturing, and regional Commercial teams to deliver a globally aligned strategy and launch plan.
• Communicate recommendations to senior leaders and governance bodies, identifying uncertainties, trade-offs, risks, and required actions.
• Build and lead a high-performing kidney commercial team.

Benefits

• Annual bonus and annual equity awards.
• Medical, dental, and vision benefits.
• Generous paid time off, including a week-long company shutdown in the summer and winter.
• Educational assistance programs, including student loan repayment.
• Commuting subsidy.
• Matching charitable donations.
• 401(k).

What This Job Offers

• Job Type: Full-time
• Career Level: Executive