Executive Director, GCS Kidney — POVE

Vertex Pharmaceuticals • Boston, MA

1d • $260,600 - $390,800 • Hybrid

About The Position

The Executive Director, Global Commercial Strategy (GCS) Kidney – Pove will be the senior commercial leader for povetacicept across kidney indications, including immunoglobulin A nephropathy (IgAN) and primary membranous nephropathy (pMN). The role owns the global commercial strategy for the kidney franchise, supporting the near-term U.S. launch and subsequent global launches in IgAN while advancing pMN toward commercialization.

The Executive Director will co-lead the povetacicept Kidney Program Team with the Development Lead, guiding program strategy and key development, lifecycle, and investment decisions. The role leads global launch execution and lifecycle management in IgAN and develops the global commercialization and launch strategy for pMN. It also partners across functions and regions to align strategy and launch plans, communicates recommendations to senior leaders and governance bodies, and builds a high-performing kidney commercial team.

Vertex is a global biotechnology company that invests in scientific innovation. The company encourages continuous learning and thoughtful adoption of advances in AI, technology, automation, and industry trends to improve decision-making, innovation, efficiency, and patient outcomes. This role is hybrid-eligible or on-site eligible: employees may choose to work remotely up to two days per week or on-site five days per week with ad hoc flexibility. Flex status is subject to company policy and may change.

The base salary range is $260,600–$390,800. The role is eligible for an annual bonus and annual equity awards; some roles may also be eligible for overtime pay in accordance with federal and state requirements. Actual base pay depends on skills, competencies, experience, and other job-related factors permitted by law.

Requirements

• Bachelor’s degree in business, marketing, life sciences, healthcare, or a related field.
• Extensive biopharmaceutical commercial experience, including global commercial strategy, new product planning, or marketing leadership.
• Demonstrated experience leading global launch strategy and execution for specialty or rare disease products.
• Strong experience in lifecycle management, commercial development, forecasting, evidence strategy, and investment decision-making.
• Launch or development experience in nephrology, specialty, rare disease, immunology, or other complex markets.
• Exceptional strategic thinking, analytical rigor, business judgment, communication, and influencing skills.
• Proven people leadership and ability to build collaborative, high-performing teams.
• Commitment to continuous learning and thoughtful adoption of capabilities that improve decision-making, innovation, efficiency, and patient outcomes.

Nice To Haves

• Advanced degree such as an MBA, M.S., Pharm.D., Ph.D., or M.D.
• Direct kidney experience.
• Program-team leadership experience.

Responsibilities

• Co-lead the povetacicept Kidney Program Team with the Development Lead, setting integrated strategy, priorities, and decision frameworks across IgAN and pMN.
• Own the global commercial strategy for povetacicept in kidney, connecting launch, lifecycle, development, evidence, and investment priorities across the franchise.
• Lead GCS support for the U.S. IgAN launch and subsequent global launches, including strategy, critical success factors, regional alignment, readiness, and execution.
• Own global lifecycle management for povetacicept in IgAN, advancing opportunities to strengthen differentiation, expand patient impact, generate evidence, and maximize long-term value.
• Lead the global commercialization and launch strategy for pMN, including market development, positioning, target product profile, evidence needs, value proposition, launch sequencing, and readiness.
• Shape development plans and lead commercial development activities across IgAN and pMN, including market research, forecasting, competitive intelligence, scenario planning, evidence requirements, and business cases.
• Develop deep understanding of IgAN and pMN markets, patients, treatment pathways, competition, access dynamics, and success requirements.
• Align the kidney strategy with the broader povetacicept portfolio by partnering with GCS leaders for non-kidney indications while maintaining clear accountability by vertical.
• Partner with Development, Medical, Regulatory, Value & Access, Finance, Manufacturing, and regional Commercial teams to deliver a globally aligned strategy and launch plan.
• Communicate recommendations to senior leaders and governance bodies, identifying uncertainties, trade-offs, risks, and required actions.
• Build and lead a high-performing kidney commercial team as the franchise advances.

Benefits

• Annual bonus eligibility.
• Annual equity awards eligibility.
• Medical, dental, and vision benefits.
• Generous paid time off, including a week-long company shutdown in the Summer and the Winter.
• Educational assistance programs, including student loan repayment.
• Commuting subsidy.
• Matching charitable donations.
• 401(k).
• Overtime pay may be available for some roles in accordance with federal and state requirements.

What This Job Offers

• Job Type: Full-time
• Career Level: Executive