Executive Director, Commercial & Medical Systems

Stoke Therapeutics•Bedford, MA

1d•$280,000 - $330,000•Hybrid

About The Position

Stoke Therapeutics is seeking an experienced, hands-on Executive Director, Commercial & Medical Systems to build and lead the technology foundation for its first commercial launch, anticipated in early 2028. Reporting to the SVP & Chief Information Officer, this leader will head Commercial & Medical Systems IT and serve as the IT partner to Commercial, Medical Affairs, Patient Services, Market Access, and related functions. The role owns the technology roadmap, implementation, integrations, vendor performance, and controls; business teams retain ownership of their strategies, processes, priorities, and adoption. The leader will deliver launch readiness and the commercial and medical technology stack, including Salesforce platforms, content review and medical information systems, patient services hub and contact center capabilities, and digital engagement platforms. The role will also establish data integrations and reporting foundations, ensure appropriate compliance and system controls, manage transparency reporting capabilities, and oversee investment planning, vendors, budgets, and program delivery. The position is open to local hybrid or remote candidates, with travel to Stoke headquarters as needed. Stoke is currently located in Bedford, Massachusetts, and expects to move its headquarters to Waltham, Massachusetts by the end of 2026. Stoke describes its work arrangements as flexible, balancing individual needs with business needs and periodic in-person collaboration.

Requirements

Bachelor’s degree required.
15+ years of IT or business systems experience in biopharma, including 8+ years leading commercial and/or Medical Affairs technology.
Has led the technology build for at least one pharmaceutical or biotech product launch; ideally, a first launch at a company building commercial capability from the ground up.
Deep knowledge of life sciences commercial platforms, including Salesforce-based CRM for pharma field and medical teams, content management and MLR review, medical information and inquiry management, patient services hub programs, contact center platforms, field data and analytics, digital engagement and web/CMS platforms, and commercial data providers.
Strong understanding of regulatory and compliance requirements for commercial and medical systems, including HIPAA, consent management, promotional compliance, sample accountability, and aggregate spend/transparency reporting.
Demonstrated success managing vendors, implementation partners, and multi-year program budgets.
Executive-level communication skills.
Hands-on leadership ability and comfort operating as both strategist and doer in a small, fast-moving team.

Nice To Haves

Advanced degree.
Experience implementing Salesforce Life Sciences Cloud or Health Cloud as an in-house patient services hub, and integrating a contact center platform such as Genesys or Five9 with Salesforce.
Experience with adverse-event intake and handoff to pharmacovigilance from patient-facing systems.
Experience with Veeva Vault PromoMats for MLR review and medical information platforms such as MedComms or comparable tools.
Orphan or ultra-rare disease launch experience, including claims-based patient identification platforms, rare disease registries, or specialty hub and pharmacy integrations.
Experience standing up commercial data warehousing and analytics.

Responsibilities

Deliver the technology roadmap for the commercial and medical launch stack, aligned with the launch plan and field organization build-out through 2027, while supporting ongoing Medical Affairs operations and pipeline expansion.
Identify platform capabilities and enhancements that support business objectives and work with functional system owners to prioritize implementation.
Support business owners’ launch readiness by establishing test environments and user acceptance testing plans, training materials, support coverage, escalation paths, and contingency plans; operate the live stack with ITIL-based incident, change, and release management.
Partner with IT Technology Services on day-one readiness for field hires, including devices, access, training, and the field support model.
Plan the post-launch Commercial & Medical Systems IT team and operating model for future budget cycles.
Lead implementation and integration of Salesforce as Stoke’s commercial, medical, and patient services platform, including Sales, Life Sciences, and Marketing Cloud.
Contract, implement, and integrate platforms for content review, medical information, field enablement, advisory boards, KOL engagement, speaker programs, digital engagement, and web.
Deliver the patient services hub on Salesforce Life Sciences Cloud with the Patient Services team, translating patient journey mapping into configuration, case and program workflows, and integrations with specialty pharmacy, benefits verification, copay, and pharmacovigilance partners.
Implement a Salesforce-integrated contact center platform for voice and text, IVR, skill-based routing, consent-managed recording, and adverse-event routing to Pharmacovigilance.
Serve as the accountable IT partner to Commercial Operations, Medical Affairs, Patient Services, Market Access, Trade & Distribution, Regulatory Advertising & Promotion, and Corporate Communications; translate launch requirements into capabilities, data flows, budgets, and timelines.
Co-own the commercial and medical systems roadmap with business system owners, agree priorities and sequencing, and run joint governance through the Commercial IT steering committee.
Design the commercial and medical data foundation and integrations that support reporting and analytics and feed the enterprise data warehouse in accordance with enterprise architecture and integration standards.
Ensure systems capture and provide complete, standardized data for reporting, analytics, and downstream applications; partner with business owners to validate data completeness, quality, and usability.
Implement and maintain launch-system controls defined by Legal, Compliance, and Privacy, including HIPAA and business associate agreements, patient consent and recording retention, TCPA, applicable sample accountability, and SOX/ITGC controls.
Define and enforce role-based access, including separation of commercial and medical users and data in shared platforms; support development of system-use SOPs and apply Stoke’s review process for vendor-embedded AI.
Deliver aggregate spend and transparency reporting capabilities, including Open Payments and state-law reporting, HCP spend capture, reporting platforms, data quality, and reconciliation processes.
Manage the Commercial & Medical Systems IT investment plan, business cases, platform evaluations, pillar budget, vendor and implementer performance, license utilization, and renewals with Finance, Procurement, and Legal.
Deliver programs through the IT PMO and report status, risks, and decisions to the CIO and launch leadership.