Distinguished Scientist, Systems Toxicology

Sanofi • Cambridge, MA

1d • Hybrid

About The Position

The Distinguished Scientist, Systems Toxicology provides scientific leadership in applying multi-omics datasets and systems biology to predict safety liabilities, investigate mechanisms of toxicity, and assess human relevance. The role connects molecular and phenotypic datasets to generate testable hypotheses, guide experimental investigations, and inform decisions across drug discovery and development. Knowledge of regulatory safety requirements for pharmaceutical drug development is also necessary.

Within Toxicology Innovation, this senior, hands-on individual contributor shapes the scientific direction of omics-based safety assessment and leads development of robust analytical workflows. Working across Toxicology Innovation and with project toxicologists and scientific advisors, the role translates biological questions into integrated analyses and actionable scientific insights. It leads complex investigations, establishes analytical approaches and standards, mentors scientists across disciplines, and builds capabilities to strengthen safety assessment across the portfolio, with global scientific influence.

Sanofi's Preclinical Safety department is a global, science-driven organization focused on data-informed safety assessments that support development of medicines. The Global Toxicology Innovation group works across computational science, biology, and drug development to advance toxicity prediction, mechanistic understanding, and clinical translatability.

Requirements

• MS plus 8 years of experience or PhD plus 5 years of experience.
• Expertise in systems biology, computational biology, bioinformatics, or a related discipline, with extensive research experience and demonstrated independent leadership of complex investigations.
• Deep hands-on expertise in transcriptomics and demonstrated experience integrating multiple molecular or phenotypic data types.
• Strong proficiency in R and/or Python and relevant bioinformatics tools.
• Expertise in pathway and network analysis, molecular signatures, and hypothesis generation.
• Substantial experience applying systems approaches to toxicology, safety assessment, or closely related mechanistic research in pharmaceutical or biotechnology settings.
• Understanding of how preclinical safety data translates to human safety and ability to translate scientific vision into actionable roadmaps and connect digital toxicology to broader R&D strategy.
• Ability to communicate complex analyses clearly to experimental scientists, computational specialists, project teams, and senior leaders.
• Strong toxicological judgment, scientific independence, hands-on analytical capability, and ability to build productive partnerships across disciplines.
• Strong knowledge of regulatory safety requirements in pharmaceutical drug development.

Responsibilities

• Provide scientific direction for systems toxicology, defining approaches for applying omics and integrative biology to priority safety questions.
• Lead integrated analyses of complex biological datasets, connecting transcriptomics with complementary data such as proteomics, metabolomics, imaging, pathology, and functional assays.
• Generate and prioritize mechanistic hypotheses using pathway analysis, network biology, molecular signatures, and existing biological knowledge.
• Establish reproducible and scalable analytical workflows spanning data processing, quality assessment, statistical analysis, visualization, and reporting.
• Drive cross-functional investigations across Preclinical Safety, connecting early screening, complex models, and investigative studies with molecular mechanisms.
• Provide scientific leadership across project teams and global functions, working with project toxicologists and scientific advisors to define decision-relevant questions and communicate integrated findings.
• Demonstrate scientific and portfolio impact, serving as a scientific authority and mentor across the global organization.
• Lead complex investigations, establish analytical approaches and standards, mentor scientists across disciplines, and build capabilities that strengthen safety assessment across the portfolio.

Benefits

• Health and wellbeing benefits, including high-quality healthcare, prevention and wellness programs.
• At least 14 weeks’ gender-neutral parental leave.
• Rewards package recognizing employee contributions.
• Opportunities for talent growth and career development, including promotion or lateral moves, domestically or internationally.
• Employees may be eligible to participate in company employee benefit programs.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior