Director/Team Lead, Valuation Center of Excellence (CoE)

Pfizer • New York, NY

5d • $176,600 - $294,300 • Hybrid

About The Position

The Valuation CoE Team Lead is accountable for financial valuation of R&D investment decisions and analytical support for business case development. The role ensures that asset- and indication-level valuations presented to Asset Teams, Category Leadership, and Executive Governance are objective, consistent, and based on common standards, supporting comparable program and portfolio prioritization.

This is primarily a Decision Analysis leadership role requiring strong valuation and modeling expertise. The Team Lead partners with Therapeutic Area-aligned Decision Analysis Directors to define decision frameworks, translate development options into aligned scenarios and sensitivities, and independently challenge assumptions from Commercial, Clinical, Regulatory, and Finance. The role owns valuation methodology and financial standards, and develops valuation tools and their integration with forecasting, development cost, PTRS, and portfolio systems.

The Team Lead advances AI-enabled valuation and decision-support workflows and develops junior Decision Analysis talent. The role reports to the Head of PDA Decision Analysis and has 3–4 Senior Managers/Managers as direct reports. Key interfaces include Therapeutic Area Decision Analysis Directors, Enterprise Portfolio Management, Finance, Commercial, Business Development/Corporate Development, and Digital.

Requirements

• BA/BS degree in life science, finance, engineering, or a quantitative discipline.
• At least 8 years of experience in management consulting, investment banking, equity research, corporate or R&D finance, portfolio management, or decision analysis, including at least 3 years building pharmaceutical asset valuations.
• Demonstrated expertise in expected cash flow modeling and economic value measures such as eNPV and eIRR, and in decision analysis techniques such as decision trees, Monte Carlo simulation, multi-attribute analysis, and value of information.
• Expert command of pharmaceutical R&D economics, including phase transition probabilities, development cost and timeline drivers, indication sequencing, exclusivity, and loss of exclusivity.
• Demonstrated experience setting analytical standards and enforcing them across teams the role does not control.
• Hands-on tool-building capability: advanced Excel plus at least one of Python, R, or equivalent, and practical use of AI/large language model tools within an analytical workflow, such as Claude, Gemini, or Copilot.
• Experience managing, mentoring, or formally coaching junior colleagues.
• Excellent Microsoft Excel and PowerPoint skills.
• Candidates must be authorized to be employed in the U.S. by any employer; permanent U.S. work authorization is required. U.S. work visa sponsorship is not available.

Nice To Haves

• Advanced degree in business, decision analysis, engineering, medicine/science, or a related quantitative field.
• Experience supporting business development, licensing, or M&A valuation alongside internal pipeline work.
• Experience deploying AI or large language model tooling in a regulated or controls-sensitive environment, including validation and audit considerations.
• Experience in a center of excellence, shared service, or other capability-based analytics team.
• Experience and expertise in portfolio management and portfolio analytics systems.
• Breadth of diverse leadership experiences and capabilities, including influencing and collaborating with peers, developing and coaching others, and overseeing and guiding colleagues’ work to achieve meaningful outcomes and business impact.

Responsibilities

• Set and execute the roadmap for AI-assisted valuation and decision-support workflows, deciding where work should be automated, augmented, or retained as human judgment.
• Design reusable prompts, agents, and workflows across approved generative AI platforms to accelerate model development, assumption retrieval, scenario generation, quality checks, and executive deliverables.
• Identify and automate recurring analytical tasks; evaluate emerging AI technologies and recommend adoption strategies with Enterprise Portfolio Management, Digital, and other business partners.
• Establish AI governance, validation, traceability, and human-review controls to ensure machine-assisted outputs are transparent, reproducible, and suitable for governance use.
• Partner with Therapeutic Area Decision Analysis Directors to frame and pressure-test business questions, decision criteria, options, and key uncertainties before modeling begins.
• Apply Decision Quality methods—including decision hierarchies, strategy tables, decision trees, scenario planning, and value of information—to structure complex choices.
• Translate development strategies and trade-offs into AI-enabled analytical frameworks, probabilistic analyses, sensitivities, and clear asset- and indication-level value drivers.
• Objectively challenge Commercial, Clinical, Regulatory, and Finance assumptions and convert complex findings into concise, actionable recommendations.
• Flexibly lead decision analysis projects in any therapeutic area when capacity issues or peak project volume arise.
• Together with the Head of PDA Decision Analysis and Therapeutic Area Decision Analysis Directors, own valuation metrics used for portfolio prioritization and investment decisions at the Portfolio Management Team.
• Own PDA’s Common Analytical Practices, including cash flow architecture, risk adjustment, discount rates, eNPV, eIRR, PTRS benchmarks, and standards for approved deviations.
• Serve as final quality reviewer for internal pipeline valuations, ensuring consistent assumptions, cross-asset comparability, transparent documentation, and audit-ready outputs before governance review.
• Maintain standardized model templates, version control, reusable analytical frameworks, and an AI-enabled knowledge repository on the Common Analytic Platform.
• Align input and reconciliation standards with Enterprise Portfolio Management, Finance, Commercial, Business Assessment, R&D, and Business Development across internal and external opportunities.
• Lead the Valuation CoE team, including performance management, work assignment, intake, prioritization, and capacity balancing across therapeutic areas.
• Build team capability in valuation, decision analysis, therapeutic-area knowledge, executive storytelling, and effective use of generative AI for analytical decision support.
• Coach and develop colleagues through clear career paths, stretch assignments, asset-team exposure, peer review, and post-decision learning.
• Establish a culture of analytical excellence, continuous improvement, knowledge sharing, and accountable delivery.
• Integrate asset- and indication-level valuations across R&D, Commercial, Finance, and Enterprise Portfolio Management to support operating plans, long-range forecasts, and portfolio prioritization.
• Create executive-ready presentations, business cases, dashboards, and briefing materials that communicate value drivers, scenarios, risks, and recommendations.
• Represent asset- and indication-level valuation methodology and findings at Category, Portfolio Management Team, and other governance forums to enable transparent, data-driven investment decisions.

Benefits

• 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution.
• Paid vacation, holiday, and personal days.
• Paid caregiver/parental and medical leave.
• Medical, prescription drug, dental, and vision coverage.
• Eligibility to participate in Pfizer’s Global Performance Plan with a bonus target of 20.0% of base salary.
• Eligibility to participate in a share-based long-term incentive program.
• Relocation assistance may be available based on business needs and/or eligibility.

What This Job Offers

• Job Type: Full-time
• Career Level: Director