Director of Office of the CEO, Founder in Residence
About The Position
BillionToOne is hiring a Director, Office of the CEO for its newly launched Founder in Residence Program. Over the program’s 12 to 18 months, the Director will work directly with the CEO and Chief of Staff on the company’s highest-priority strategic and operational projects, then graduate into a permanent senior operating role at the Director or Senior Director level. The Director will take on a changing portfolio of one or two high-impact projects each quarter. Work may include supporting new product launches, shaping commercial strategy, improving operations, responding to competitive developments, and incubating business lines or capabilities. The position is intended for an entrepreneurial builder who can bring first-principles thinking, strong analytical ability, AI fluency, and a bias to action to ambiguous, fast-moving work. The role partners with teams throughout the company and involves participation in CEO meetings, ongoing presentations to the executive team, and serving as a thought partner to the CEO and Chief of Staff. The posting describes the role as hybrid, with three onsite days per week, and also states that it is an on-site position requiring relocation to the San Francisco Bay Area. It reports to the VP of Business Operations and Chief of Staff, with active co-sponsorship from the CEO.
Requirements
- 6–10+ years of building or operating experience with a record of exceptional impact in entrepreneurial or builder-oriented environments.
- One of the following backgrounds: founder of a company that has been acquired, wound down, or otherwise moved on from; senior executive (COO, CPO, or VP-level) who joined a top scaleup among its first 5 to 10 employees; or top-tier management consultant from MBB or a top boutique firm with healthcare or life sciences exposure and some operational experience.
- First-principles thinking and exceptional analytical horsepower.
- Builder mentality, bias to action, comfort with ambiguity, and ability to operate without a playbook.
- AI-native fluency and ability to use AI tools to work faster and amplify individual leverage.
- Strong written and verbal communication, including communication with executives and the Board.
- Genuine interest in molecular diagnostics and BillionToOne’s mission.
- Relocation to the San Francisco Bay Area is required.
Nice To Haves
- Prior exposure to healthcare, life sciences, molecular diagnostics, or other regulated industries.
- Track record of building from 0 to 1, such as new products, functions, business lines, or operating mechanisms.
- Existing network in the founder community, YC ecosystem, or top scaleup operating community.
Responsibilities
- Lead one or more CEO-priority strategic and operational initiatives each quarter, including work in product launches, commercial and go-to-market strategy, business development, operational excellence, competitive response, and business-line incubation.
- Identify underperforming processes, workflows, or functions; diagnose root causes, design solutions, and lead execution with cross-functional teams.
- Lead and influence teams across Sales, Product, Lab Operations, Compliance, Reimbursement, Finance, Business Development, Legal, and HR.
- Use first-principles thinking and AI tools to deliver results in ambiguous, fast-moving environments.
- Participate in CEO meetings, present regularly to the executive team, and serve as a thought partner to the CEO and Chief of Staff on company-shaping decisions.
- Build working knowledge of company functions through the projects led.
Benefits
- Multiple medical benefit options, with employee premiums paid in full for select plans and dependent coverage up to 80%.
- 16 weeks of paid Family Bonding Leave at 100% for eligible employees.
- Supplemental fertility benefits coverage.
- Retirement savings program with a 4% company match.
- Paid time off increases with tenure.
- Latest hardware, including laptops and lab equipment.
- Free daily onsite lunches from top eateries.
- On-campus state-of-the-art gym and restaurant.
- Free onsite EV charging.
- Annual bonus eligibility.
- New-hire equity grant of up to $210,000 at grant value, vesting over four years, plus annual equity refresh grants equal in value to the new-hire grant.
- Professional growth opportunities and competitive medical and dental coverage.
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What This Job Offers
Job Type
Full-time
Career Level
Director
Education Level
No Education Listed
