Director, Molecular & Cellular Immunology

Stylus Medicine • Cambridge, MA

4d

About The Position

Stylus Medicine is developing in vivo genetic medicines using engineered recombinases and non-viral delivery to encode therapeutics. The company’s platform may have applications in oncology, autoimmune and genetic diseases, and beyond.

The Director, Molecular & Cellular Immunology will apply deep immunology expertise to collaboratively develop non-viral in vivo CAR-T therapies. Reporting to the SVP, Immunology, this person will lead the Molecular & Cellular Immunology team and oversee in vitro workflows that deepen mechanistic understanding of the Stylus platform in immune cells, support platform innovation, advance the lead CAR-T program toward development candidate nomination, and prepare for clinical advancement. The role is a scientific thought partner to the SVP of Immunology, a collaborator across the scientific team, and a driver of the company’s in vivo immune therapy work.

Requirements

• PhD in Molecular or Cellular Biology, Virology, Immunology, or a related field, with deep immunology expertise.
• At least 8 years of post-graduate experience, including a minimum of 5 years in drug discovery in the pharmaceutical and/or biotechnology industry.
• Proven track record of leading immunology, immunotherapy, or engineered immune cell therapy programs from early drug discovery to IND, with CAR-T experience.
• Demonstrated accomplishments such as patents, new initiatives, IND preparation, or publications.
• Expertise in immune-modulating molecule design and design-test-optimize cycles for functional evaluation of immune-relevant gene and cell therapy cargos.
• Experience managing and developing scientists as direct reports.
• Ability to excel in internal and external cross-functional collaborations.
• Ability to think critically, synthesize clear principles from complex datasets, and communicate them effectively.

Nice To Haves

• Experience with T-cell-engaging bispecific antibodies and antibody discovery.

Responsibilities

• Conceptualize in vivo T-cell therapeutic product candidates using the Stylus non-viral recombinase engineering platform, and develop molecular designs to realize these concepts.
• Develop experimental strategies and immune cell-based testing systems to evaluate candidate functional performance for development candidate nomination and preclinical data package generation.
• Work with direct reports to focus experimental design and execution on key scientific questions and problems for the lead program and platform innovations, contributing hands-on in the lab as necessary.
• Lead, manage, mentor, and develop a team of direct-report scientists.
• Apply immunology expertise in collaboration with multidisciplinary team members and external partners to execute programs consistent with overall strategy.
• Communicate scientific concepts, strategies, status updates, and experimental results across the organization and to high-level stakeholders.
• Drive results with speed and rigor while maintaining awareness of timelines, milestones, and budgets.
• Monitor literature and technologies in the field to inform innovation, and present Stylus data externally as appropriate.
• May lead or manage collaborations with academic, CRO, and corporate partners to advance programs.

What This Job Offers

• Job Type: Full-time
• Career Level: Director
• Education Level: Ph.D. or professional degree