Director, Molecular & Cellular Immunology

Stylus Medicine • Cambridge, MA

4d • $225,000 - $240,000

About The Position

Stylus Medicine is developing in vivo genetic medicines using engineered recombinases and non-viral delivery to encode therapeutics. Its platform is intended for potential use in oncology, autoimmune and genetic diseases, and other areas.

The Director, Molecular & Cellular Immunology will apply deep immunology expertise to collaboratively develop non-viral in vivo CART therapies. Reporting to the SVP, Immunology, this person will lead the Molecular & Cellular Immunology team and oversee execution of in vitro workflows. The work will deepen mechanistic understanding of the Stylus platform in immune cells, support platform innovation, advance the lead CART program toward development candidate nomination, and prepare for clinical advancement. The Director will partner scientifically with the SVP of Immunology, collaborate with the broader scientific team, and contribute to the company’s in vivo immune therapy mission.

Requirements

• PhD in Molecular or Cellular Biology, Virology, Immunology, or a related field, with deep immunology expertise.
• At least 8 years of post-graduate experience, including a minimum of 5 years of drug discovery experience in the pharmaceutical and/or biotechnology industry.
• Proven track record leading immunology, immunotherapy, or engineered immune cell therapy programs from early drug discovery to IND, with CART experience.
• Demonstrated accomplishments such as patents, new initiatives, IND preparation, and publications.
• Expertise in immune-modulating molecule design and applying design-test-optimize cycles to functionally evaluate immune-relevant gene and cell therapy cargos.
• Experience managing and developing scientists as direct reports.
• Ability to excel in internal and external cross-functional collaborations.
• Ability to think critically, synthesize simple principles from complex datasets, and communicate them effectively.

Nice To Haves

• Experience in T cell-engaging bispecific antibodies and antibody discovery.

Responsibilities

• Conceptualize in vivo T cell therapeutic product candidates using the Stylus non-viral recombinase engineering platform and develop molecular designs to realize them.
• Develop experimental strategies and immune cell-based testing systems to evaluate candidate functional performance for development candidate nomination and preclinical data package generation.
• Work with direct reports to focus experimental design and execution on key scientific questions for the lead program and platform innovations; make hands-on lab contributions as necessary.
• Lead, manage, mentor, and develop a team of direct-report scientists.
• Apply immunology expertise in collaboration with multidisciplinary team members and external partners to execute programs consistent with overall strategy.
• Communicate scientific concepts, strategies, status updates, and experimental results across the organization and to high-level stakeholders.
• Deliver results with speed and rigor while maintaining awareness of timelines, milestones, and budgets.
• Monitor current literature and technologies to inform or inspire innovation, and present Stylus data externally as appropriate.
• Lead or manage collaborations with academic, CRO, and corporate partners as needed to advance programs.

What This Job Offers

• Job Type: Full-time
• Career Level: Director
• Education Level: Ph.D. or professional degree