Director, Commercial Development

Madrigal Pharmaceuticals • Conshohocken, PA

5d • $214,000 - $261,000 • Hybrid

About The Position

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH. Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c). Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way. The Director, Commercial Development, will be a critical member of the US Marketing and Commercial organizations who will help build the future of Madrigal. This is truly a unique opportunity to make a difference for the betterment of patients living with MASH. This individual will be responsible for representing the global commercial perspective across the Madrigal pipeline, ensuring development, commercialization strategy, and launch planning reflect and are fully aligned to commercial priorities. This role serves as a key stakeholder interfacing with study and program teams, providing strategic guidance on target product profiles (TPP), market positioning, clinical development prioritization, and commercial readiness to maximize portfolio value. The Director will work cross-functionally with RD, Medical Affairs, Market Access, Commercial Strategy and Regulatory to shape the development path and commercialization strategy. The role requires deep expertise in specialty pharma market dynamics, competitive intelligence, payer landscape, and commercial strategy, to provide insightful feedback and inform global decisions from early development through launch and lifecycle management.

Requirements

• Proactive, self-starter and independent worker motivated by challenges and delivering results (business owner mindset)
• Strategic thinker with strong commercial acumen and ability to balances near-term development priorities with long-term asset value
• High learning agility and problem-solving skills with ability to multi-task across several projects
• Data-driven decision maker with strong analytical skills to quickly diagnose problems and develop fit-for-purpose solutions
• Ability to influence without formal authority to drive cross-functional alignment
• Ability to execute and thrive in fast-paced environments filled with ambiguity
• Superb communication skills, both verbal and written
• Desire to professionally develop and gain more responsibilities resulting in greater impact
• Bachelor's Degree required
• Candidate must have 12-15+ years of biopharmaceutical marketing and/or commercial development experience
• Must have direct commercial development experience working on assets across the product lifecycle, in particular, from pre-commercialization to launch

Nice To Haves

• advanced degree preferred
• Experience with MASH or related therapeutic areas is a plus
• Strong scientific background is a plus
• Experience in smaller company (or team) environments is a plus

Responsibilities

• Provide commercial input on indication prioritization, endpoints, comparator strategy, and trial design.
• Identify label-optimizing opportunities and evidence needs to support global approval, access and adoption.
• Support market landscape and market research analyses: epidemiology, treatment pathways, competitive pipelines and emerging modalities.
• Partner with Commercial Strategy & Operations, Medical Affairs and Thought Leadership to surface signals that drive strategic shifts.
• Collaborate on revenue forecasting, scenario planning and pricing/market uptake assumptions.
• Inform investment, launch sequencing and lifecycle decisions with commercial assessments.
• Support cross-functional commercialization planning with Sales, Marketing, Market Access, Patient Access, Thought Leadership, Communications and Medical Affairs for coordinated launch readiness and market shaping.
• This role ensures the product is developed and positioned to achieve maximum clinical adoption and commercial success in the U.S. market by embedding U.S. evidence, access and commercialization needs into global development and launch decisions.

Benefits

• flexible paid time off
• medical, dental, vision and life/disability insurance
• 401(k) offerings (i.e., traditional, Roth, and employer match)
• supplemental life insurance
• legal services
• mental health benefits through our Employee Assistance Program for employees and their family

What This Job Offers

• Job Type: Full-time
• Career Level: Director