Director, Clinical Sciences

Tango Therapeutics • Boston, MA

7d

About The Position

Tango Therapeutics is a biotechnology company focused on discovering novel drug targets and developing precision medicines for cancer. The Director, Clinical Sciences is a hands-on role making scientific contributions to one or more clinical development programs. The position actively supports the design, execution, analysis, and interpretation of clinical studies, ensures scientific rigor throughout study conduct, oversees data review and analysis, and partners cross-functionally to advance clinical development programs. The role reports to the Executive Director, Clinical Sciences.

The Director provides scientific leadership for early- and late-stage oncology clinical trials, contributes to clinical and regulatory documents and health authority interactions, and interprets emerging clinical, safety, PK/PD, and biomarker data to guide study conduct, dose selection, expansion opportunities, and development strategy. The position also helps foster a collaborative, accountable, and scientifically rigorous culture within Clinical Science and may perform additional duties as required.

Requirements

• MD, PhD, PharmD, or MS in a relevant scientific discipline.
• At least 10 years of experience in clinical science or research.
• At least 5 years of experience in oncology.
• Demonstrated experience designing and managing clinical trials, including knowledge of regulatory guidelines and GCP.
• Strong analytical skills, with proficiency in statistical analysis and interpretation of clinical data.
• Excellent written and oral communication skills, including the ability to convey complex scientific concepts to diverse audiences.
• Experience working in a fast-paced environment.

Responsibilities

• Contribute scientifically to one or more clinical programs to support successful study design, execution, and interpretation.
• Provide scientific leadership throughout the design, execution, analysis, and interpretation of early- and late-stage oncology clinical trials.
• Partner with Clinical Development physicians, Clinical Operations, Biostatistics, Clinical Pharmacology, Pharmacovigilance, Regulatory Affairs, Translational Medicine, and Medical Writing to support high-quality clinical program execution.
• Contribute to the development and review of protocols, investigator brochures, informed consent forms, clinical study reports, clinical development plans, and regulatory briefing materials.
• Interpret emerging clinical, safety, PK/PD, and biomarker data to inform study conduct, dose selection, expansion opportunities, and overall development strategy.
• Contribute scientific expertise to regulatory submissions and health authority interactions.
• Foster a collaborative, accountable, and scientifically rigorous culture within the Clinical Science function.
• Perform additional duties and responsibilities as required.

What This Job Offers

• Job Type: Full-time
• Career Level: Director