Development Asset Leader, Liver Franchise

Prime Medicine•Cambridge, MA

10d•$360,000 - $408,000•Hybrid

About The Position

Prime Medicine is seeking an experienced, strategic, and operationally rigorous Development Asset Leader to lead its in vivo LNP-delivered liver programs as they advance from early clinical development through licensure, beginning with Wilson's Disease and Alpha-1 Antitrypsin Deficiency. The role takes ownership of a liver program after it clears IND and leads the asset through clinical proof of concept and regulatory approval or licensure. As the liver portfolio grows, the leader will build the processes, governance, and team structure needed to advance multiple concurrent clinical assets and deploy company resources effectively. The Asset Leader will engage internal stakeholders, including executive management and the Board, and external stakeholders such as regulatory authorities, key opinion leaders, and CRO/CDMO leadership. The role leads a cohesive cross-functional team, fosters collaboration in a lean organization, and holds the asset accountable for timelines, budget, and scientific rigor. The position is based in Cambridge, Massachusetts, with a minimum of three onsite days per week, and reports to the VP, Programs and Strategy.

Requirements

12 or more years of drug development experience in biotech or pharma.
Demonstrated leadership of a clinical-stage asset from IND through late-stage development.
Track record of cross-functional program leadership and accountability spanning Clinical, Regulatory, CMC, and Nonclinical.
Ability to influence without formal authority, build team culture, and manage external partners as an extension of the internal team.
Comfort operating in a lean, resource-constrained organization and building capability.

Nice To Haves

Advanced degree in life sciences, medicine, or a related field (PhD, MD, or PharmD); equivalent industry experience is considered.
Direct experience in genetic medicines, including gene or gene-editing therapies or RNA-based therapeutics, or in rare disease.
Liver-directed or LNP delivery experience.
Experience or genuine interest in applying AI tools to project or portfolio management.

Responsibilities

Own the Integrated Development Plan for liver assets from IND acceptance through regulatory approval or licensure, including trial design input, data package strategy, and key go/no-go decisions.
Anticipate, frame, and escalate critical considerations that materially change an asset's risk/value profile to executive management.
Lead a matrixed team spanning Clinical, Regulatory, CMC/Manufacturing, Biostatistics, Pharmacovigilance, Medical Affairs/Patient Advocacy, and Commercial.
Deploy AI-enabled project management tools where appropriate, including timelines, risk registers, and cross-functional dashboards.
Help design team structure, governance cadence, and knowledge-transfer processes as the liver franchise expands.
Serve as a key point of contact with CROs/CDMOs, KOLs, and patient advocacy groups for the asset.
Represent the asset in regulatory interactions alongside Regulatory Affairs.