Associate Scientist, Purification Process

Thermo Fisher Scientific•Wilmington, DE

3d•Onsite

About The Position

Thermo Fisher Scientific is hiring an Associate Scientist to support downstream process development and optimization for novel therapeutic monoclonal antibody and bispecific products throughout the clinical lifecycle. The role is fully onsite at a customer site in Wilmington, Delaware, and is part of the Laboratories Functional Service Partnership team, which provides sustained support within customer organizations. Applicants must be legally authorized to work in the United States without sponsorship and must pass a comprehensive background check, including drug screening. Relocation assistance is not provided. The scientist will contribute to purification process development, optimization, and scale-up; provide purified material to formulation and cell culture teams; analyze in-process samples; and document and communicate work. The position requires foundational knowledge of protein chemistry and bioprocessing, with experience in chromatography, filtration, protein analysis, and ultrafiltration/diafiltration considered beneficial. The role is based in a laboratory setting. Work may involve standing or remaining stationary for typical working hours, lifting and moving objects up to 25 pounds, working in non-traditional environments, and possible exposure to potentially hazardous elements such as infectious agents. The successful candidate should be able to communicate effectively, learn and use standard office equipment and technology, and manage multiple activities under pressure.

Requirements

BS or MS degree in biochemistry, bioengineering, biology, chemistry, or a related field; an equivalent combination of appropriate education, training, and/or directly related experience may be considered.
Basic knowledge of protein chemistry and bioprocessing.
Good verbal and written communication skills.
Organized, collaborative, independent, and meticulous.
Legally authorized to work in the United States without sponsorship.
Able to pass a comprehensive background check, including drug screening.
Able to communicate and understand information and ideas with diverse groups of people.
Able to work upright and stationary and/or standing for typical working hours.
Able to lift and move objects up to 25 pounds.
Able to work in non-traditional work environments and use and learn standard office equipment and technology.
Able to perform successfully under pressure while prioritizing and handling multiple projects or activities.

Nice To Haves

Up to 2 years of relevant industry experience is preferred.
Basic knowledge and preferably hands-on experience with column or membrane chromatography, including affinity, size-exclusion, ion-exchange, and multi-mode chromatography, and filtration technology.
Experience in protein analysis such as HPLC, ELISA, pH, conductivity, and A280 concentration testing.
Hands-on experience or basic knowledge of ultrafiltration/diafiltration experimentation and TFF systems.
Inventory management skills.

Responsibilities

Perform or assist with purification process development, optimization, and scale-up manufacturing.
Conduct protein purification to support formulation team material needs and cell culture development.
Perform routine analysis of in-process samples using relevant product-purity and process-impurity analytical tools.
Prepare buffers and solutions needed for laboratory work.
Present work summaries in a weekly group meeting.
Write routine electronic laboratory notebook entries.
Perform other responsibilities as assigned.