Associate Scientist, Bioanalytical Assays

Flagship Pioneering•Cambridge, MA

About The Position

Serif Biomedicines is seeking an experienced Associate Scientist to drive bioanalytical assays for its novel DNA platform. The role focuses broadly on in vitro and in vivo assays and calls for scientific rigor, intellectual curiosity, enthusiasm, and a desire to innovate new nucleic acid therapeutics. The successful candidate will work in a dynamic, fast-paced entrepreneurial environment, both independently and as part of a highly collaborative, rapidly growing team. The Associate Scientist will develop, optimize, execute, and analyze bioassays and ligand-binding assays supporting in-house and CRO studies. The work will assess the efficacy, safety, and biodistribution of novel nucleic acid therapeutics in rodents and non-human primates (NHPs). The role also contributes scientific and technical perspectives to platform development and requires clear communication of experimental findings. Flexibility is expected to support accelerated timelines for data generation, analysis, and reporting for in vivo studies.

Requirements

Master’s degree or bachelor’s degree in a relevant discipline, with 6+ years of industry experience; level will be based on experience.
Deep expertise in ex-vivo analytical assays such as ELISA, MSD, qPCR, and ddPCR.
Hands-on experience with multiparameter flow cytometry, including panel design, compensation, and analysis.
Proficiency in tissue processing and isolation of cell types, including hepatocytes and immune cells, from mice and NHPs.
Strong communication, interpersonal, organizational, analytical, and problem-solving skills.
Ability to thrive in a fast-paced, multidisciplinary, rapidly growing biotech environment.
Flexibility to support accelerated timelines for in vivo study data generation, analysis, and reporting.

Nice To Haves

Experience with various transfection methods in human and NHP PBMCs.
Prior experience in nucleic acid therapeutics or LNPs.
Experience analyzing histological techniques, including IHC/IF, ISH, and H&E.

Responsibilities

Execute and analyze bioassays assessing the efficacy, safety, and biodistribution of novel nucleic acid therapeutics in rodents and NHPs.
Contribute scientific and technical perspectives to advance platform development.
Develop, optimize, and execute ligand-binding assays to support studies conducted in-house and at CROs.
Communicate experimental findings effectively in oral, written, and visual formats.
Work independently and collaboratively in a multidisciplinary team environment.
Support accelerated timelines for data generation, analysis, and reporting for in vivo studies.