Associate Scientist, Bioanalytical Assays

Serif Biomedicines•Cambridge, MA

About The Position

Serif Biomedicines is seeking an experienced Associate Scientist to drive bioanalytical assays for a novel DNA platform. The role involves working with in vitro and in vivo assays and contributing scientific rigor, intellectual curiosity, enthusiasm, and innovative thinking to the development of nucleic acid therapeutics. The successful candidate will work independently and collaboratively in a dynamic, fast-paced, entrepreneurial, multidisciplinary, and rapidly growing biotech environment. The Associate Scientist will execute and analyze bioassays to assess the efficacy, safety, and biodistribution of novel nucleic acid therapeutics in rodents and non-human primates (NHPs). They will develop, optimize, and execute ligand-binding assays to support studies conducted in-house and at contract research organizations (CROs), contribute scientific and technical perspectives to platform development, and communicate experimental findings in oral, written, and visual formats. Flexibility is expected to support accelerated timelines for data generation, analysis, and reporting for in vivo studies.

Requirements

Master’s or bachelor’s degree in a relevant discipline and 6+ years of industry experience; level will be based on experience.
Deep expertise in ex-vivo analytical assays such as ELISA, MSD, qPCR, and ddPCR.
Hands-on experience with multi-parameter flow cytometry, including panel design, compensation, and analysis.
Proficiency in processing tissues and isolating cell types, including hepatocytes and immune cells, from mice and NHPs.
Strong communication, interpersonal, organizational, analytical, and problem-solving skills.
Ability to thrive in a fast-paced, multidisciplinary, rapidly growing biotech environment.
Flexibility to support accelerated timelines for in vivo study data generation, analysis, and reporting.

Nice To Haves

Experience with various transfection methods in human and NHP PBMCs.
Prior experience in nucleic acid therapeutics or LNPs.
Experience analyzing histological techniques, including IHC/IF, ISH, and H&E.

Responsibilities

Execute and analyze bioassays assessing the efficacy, safety, and biodistribution of novel nucleic acid therapeutics in rodents and NHPs.
Contribute scientific and technical perspectives to advance platform development.
Develop, optimize, and execute ligand-binding assays supporting in-house and CRO studies.
Communicate experimental findings in oral, written, and visual formats.
Work independently and collaboratively in a multidisciplinary team.
Support accelerated timelines for data generation, analysis, and reporting for in vivo studies.