Associate Scientist, Bioanalytical Assays

Flagship Pioneering, Inc.•Cambridge, MA

7d•$96,000 - $126,500

About The Position

Serif Biomedicines is seeking an experienced Associate Scientist to drive bioanalytical assays for a novel DNA platform. The role focuses on in vitro and in vivo assays and calls for scientific rigor, intellectual curiosity, enthusiasm, and a desire to innovate new nucleic acid therapeutics. The successful candidate will work independently and collaboratively in a dynamic, fast-paced, entrepreneurial environment with a multidisciplinary and rapidly growing team. The Associate Scientist will execute and analyze bioassays assessing the efficacy, safety, and biodistribution of novel nucleic acid therapeutics in rodents and NHPs; contribute scientific and technical perspectives to platform development; and develop, optimize, and execute ligand binding assays for studies conducted in-house and at CROs. The candidate will communicate experimental findings in oral, written, and visual formats and demonstrate flexibility in supporting accelerated timelines for in vivo study data generation, analysis, and reporting.

Requirements

Master's or bachelor's degree in a relevant discipline with 6 or more years of industry experience; level will be based on experience.
Deep expertise in ex-vivo analytical assays such as ELISA, MSD, qPCR, and ddPCR.
Hands-on experience with multiparameter flow cytometry, including panel design, compensation, and analysis.
Proficiency in processing tissues and isolating cell types, such as hepatocytes and immune cells, from mice and NHPs.
Strong communication, interpersonal, organizational, analytical, and problem-solving skills.
Ability to thrive in a fast-paced, multidisciplinary, rapidly growing biotech environment.
Flexibility to support accelerated timelines for in vivo study data generation, analysis, and reporting.

Nice To Haves

Experience with various transfection methods in human and NHP PBMCs.
Prior experience in nucleic acid therapeutics or LNPs.
Experience analyzing histological techniques, including IHC/IF, ISH, and H&E.

Responsibilities

Execute and analyze bioassays to assess efficacy, safety, and biodistribution of novel nucleic acid therapeutics in rodents and NHPs.
Contribute scientific and technical perspectives to advance platform development.
Develop, optimize, and execute ligand binding assays to support studies in-house and at CROs.
Communicate experimental findings effectively in oral, written, and visual formats.
Work independently and collaboratively in a multidisciplinary team environment.
Support accelerated timelines associated with data generation, analysis, and reporting for in vivo studies.