Associate Scientist, Bioanalytical Assays

Serif Biomedicines, Inc.•Cambridge, MA

7d•$96,000 - $126,500

About The Position

Serif Biomedicines is seeking an experienced Associate Scientist to drive bioanalytical assays for a novel DNA platform. The role is suited to someone who enjoys working with in vitro and in vivo assays and brings scientific rigor, intellectual curiosity, enthusiasm, and a desire to innovate new nucleic acid therapeutics. The successful candidate will work in a dynamic, fast-paced entrepreneurial environment, both independently and collaboratively as part of a multidisciplinary, rapidly growing team. The role focuses on assessing the efficacy, safety, and biodistribution of novel nucleic acid therapeutics, and on developing and executing ligand-binding assays in support of internal and CRO studies. The successful candidate will contribute scientific and technical perspectives to platform development, communicate findings in oral, written, and visual formats, and flexibly support accelerated timelines for data generation, analysis, and reporting for in vivo studies.

Requirements

Master’s or bachelor’s degree in a relevant discipline with at least 6 years of industry experience; level will be based on experience.
Deep expertise in ex vivo analytical assays such as ELISA, MSD, qPCR, and ddPCR.
Hands-on experience with multiparameter flow cytometry, including panel design, compensation, and analysis.
Proficiency in processing tissues and isolating cell types, such as hepatocytes and immune cells, from mice and NHPs.
Strong communication, interpersonal, organizational, analytical, and problem-solving skills.
Ability to thrive in a fast-paced, multidisciplinary, rapidly growing biotech environment.

Nice To Haves

Experience with various transfection methods in human and NHP PBMCs.
Prior experience in nucleic acid therapeutics or LNPs.
Experience analyzing histological techniques, including IHC/IF, ISH, and H&E.

Responsibilities

Execute and analyze bioassays assessing the efficacy, safety, and biodistribution of novel nucleic acid therapeutics in rodents and NHPs.
Contribute scientific and technical perspectives to advance platform development.
Develop, optimize, and execute ligand-binding assays to support studies conducted in-house and at CROs.
Communicate experimental findings effectively in oral, written, and visual formats.
Work independently and collaboratively in a multidisciplinary team environment.
Flexibly support accelerated timelines for data generation, analysis, and reporting for in vivo studies.