Associate Director, Pricing and Access Analytics

Amylyx Pharmaceuticals•Cambridge, MA

3d•$182,000 - $205,000•Remote

About The Position

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply. The Opportunity Amylyx is seeking an Associate Director, Pricing Strategy & Access Analytics to serve as a hands-on strategic partner within Market Access. Reporting to the Senior Director, Market Access Strategy, this individual will be responsible for helping lead pricing strategy, analytics, gross-to-net modeling, contracting evaluation, and related decision support. The role will also support broader market access priorities, including identifying actionable payer and PBM insights, monitoring coverage and channel strategy trends, and generating patient access analytics to inform decision-making. The role will translate complex access, pricing, and customer data into clear, actionable recommendations that support access to avexitide (subject to FDA approval) for patients with post-bariatric hypoglycemia (PBH), an area of significant unmet need.

Requirements

Bachelor’s degree required; advanced degree such as MBA, MPH, MS, PharmD, or related discipline preferred.
6+ years of experience in market access, pricing, contracting, analytics, finance, forecasting, patient services, or related pharmaceutical/biotech roles;
Strong understanding of U.S. pricing, gross-to-net, payer, PBM, health system, specialty pharmacy, reimbursement, and patient access dynamics.
Demonstrated ability to build analytical models, interpret complex data, and communicate practical recommendations to cross-functional and senior stakeholders.
Advanced Microsoft Excel, PowerPoint, pivot table, financial modeling, PBM/payer negotiations & scenario analysis skills
High business and P&L acumen, with a strong foundation of GTN accounting dynamics across access customer types (commercial, government, patient services, specialty pharmacy, trade & distribution)
High integrity, strong collaboration skills, and comfort operating in a fast-paced, cross-functional environment.
Ability and willingness to travel occasionally

Nice To Haves

Experience in rare disease, specialty pharmacy, launch planning, pricing strategy, contracting analytics, or patient services analytics preferred.

Responsibilities

Lead pricing analysis, scenario planning, gross-to-net modeling, rebate and contracting economics, competitive pricing assessments to inform avexitide launch price and lifecycle decisions.
Build and maintain financial models that evaluate pricing options, payer and PBM contracting opportunities, customer trade-offs, access implications, and business-case assumptions.
Partner with Sr. Director, Access Strategy and co-lead pricing committee with Market Access, Finance, Forecasting, Legal, Compliance, Commercial, and Analytics teams to align pricing assumptions, pressure-test recommendations, and support compliant decision-making. Helps maintain and operationalize pricing committee.
Monitor and analyze policy and pricing trends with potential to impact launch of avexitide
Partner with finance to help assess risk and develop mitigation solution for potential government pricing calculations and reporting
Ensure compliance and State Drug Pricing Transparency reporting.
Analyze payer coverage, utilization management, formulary positioning, reimbursement dynamics, claims trends, abandonment, reversals, pull-through performance, and patient access barriers.
In collaboration with commercial operations and market access stakeholder, develop dashboards, scorecards, customer insights, and executive-ready materials that synthesize payer, PBM, health system, specialty pharmacy, channel, and patient services trends into actionable recommendations.
Monitor external market trends, policy changes, competitive dynamics, Medicare/Medicaid reimbursement considerations, and channel evolution that may affect pricing, access, and reimbursement strategy.
Support vendor selection and management for market access data, pricing analytics, and research projects, ensuring high-quality outputs and timely delivery.