Associate Director / Director of Product Management, Signatera Hematologic Oncology (Heme)

Natera

7d • $180,300 - $230,900 • Remote

About The Position

Natera is seeking an Associate Director / Director of Product Management to own the product strategy and roadmap for Signatera in hematologic malignancies, beginning with multiple myeloma and lymphomas and extending to additional hematologic indications. Signatera is a personalized, tumor-informed test for molecular residual disease (MRD) assessment and surveillance monitoring in patients previously diagnosed with cancer.

The role combines product management, LDT market entry, evidence generation, analytics, and clinical-trial product support, including trials conducted under IUO and IVD pathways. The position works cross-functionally with the Foresight business unit, R&D, Lab Operations, Software Engineering, Medical Affairs, Marketing, Business Development, and Regulatory. The role is remote within the United States, with availability during Pacific time hours required; site presence in San Carlos, California, Boulder, Colorado, or Austin, Texas is preferred. Travel is 30–40%.

Requirements

• Bachelor’s degree in life sciences, statistics, engineering, or a related field.
• At least 5 years of experience in product management, product marketing, or market analytics at a diagnostics, biotech, or pharmaceutical company.
• Working knowledge of oncology molecular testing, next-generation sequencing (NGS), and biomarkers, including NGS bioinformatics workflows such as variant calling, filtering, and interpretation, and genomic data analysis.
• Experience with clinical trials and in IUO and IVD regulated environments.
• Experience bringing a molecular test to market as an LDT, including clinical validation and laboratory requirements.
• Experience designing or supporting clinical evidence generation, such as clinical validation studies, retrospective studies, or prospective trials.
• Understanding of MRD in multiple myeloma and lymphomas, including how blood-based testing fits with bone marrow and imaging-based MRD assessment.
• Understanding of how somatic variants are detected in whole genome sequencing and support MRD tracking in hematologic tumors.
• Understanding of LDT market-entry requirements and evidence needed for clinical adoption and payer coverage.
• Ability to translate customer and clinical needs into clear product requirements.
• Strong analytical skills, including the ability to build metrics, interpret data, and present findings.
• Basic financial modeling skills.
• Proficiency with MS Excel, Word, and PowerPoint.
• Ability to lead without authority and influence cross-functional teams.
• Strong written and oral communication skills and ability to work effectively in a highly matrixed, cross-functional environment.
• Ability to explain complex topics simply, including biomarkers, multiple indications, and regulatory pathways.
• Strong customer focus, including the ability to build relationships with thought leaders.
• Strong organization and time-management skills, including the ability to manage several projects and meet tight deadlines.
• Flexibility to balance rapid development with quality standards.
• Clear written and verbal communication with senior leadership.
• Ability to use a computer keyboard, communicate by telephone and computer, and read printed material.
• Availability during Pacific time hours.
• Willingness to travel 30–40% for advisory boards, congresses, and customer meetings.

Nice To Haves

• Advanced degree (MS, PhD, or MBA).
• Seven or more years of experience in product management, product marketing, or market analytics at a diagnostics, biotech, or pharmaceutical company.
• Hematologic oncology experience, especially in multiple myeloma and lymphoma.
• MRD experience.
• Experience with data analysis tools such as SQL, Snowflake, or similar.
• Familiarity with a high-complexity molecular laboratory, including cfDNA or plasma workflows.
• In-depth knowledge of whole genome sequencing and variant types, including structural variants, single nucleotide variants, and phased variants.
• Prior key opinion leader engagement and external customer-facing experience.
• Site-based presence in San Carlos, California, Boulder, Colorado, or Austin, Texas.

Responsibilities

• Develop and execute the Signatera product roadmap for hematologic malignancies, beginning with multiple myeloma and lymphomas and expanding to additional indications.
• Lead market-entry planning for Signatera in hematology as a laboratory developed test (LDT), covering clinical validation, CLIA and state requirements, market access and reimbursement, payer considerations, and launch readiness.
• Define product requirements for blood-based malignancies with R&D, Lab Operations, and Software Engineering, including assay, sample type, workflow, and reporting needs.
• Lead product support for clinical trials using Signatera in hematology, including IUO studies with pharmaceutical and academic partners and the path toward IVD and regulated use.
• Partner with Regulatory, Clinical, and Business Development on trial start-up, study requirements, pharmaceutical opportunities, and companion diagnostic opportunities.
• Build product performance metrics and dashboards, analyze test volume, adoption, ordering patterns, turnaround time, and retention, and use findings to prioritize improvements.
• Partner with Medical Affairs and Clinical on evidence-generation strategy and execution, including identifying clinical gaps, designing studies, working with investigators and trial partners, and planning publications and congress presentations.
• Guide development of Signatera Genome in hematology, including whole genome sequencing technology, phased variants, and structural variants; work with R&D and Bioinformatics to define how these capabilities improve tumor tracking and MRD sensitivity.
• Conduct Voice of Customer interviews, market research, and competitive and market intelligence in hematologic oncology.
• Engage key opinion leaders, advisory boards, and congresses such as ASH, EHA, and ASCO, gathering insights to guide product decisions.
• Work with Marketing on product positioning, launch plans, pricing, and key collateral.
• Build business cases and financial models to support product initiatives.
• Present strategy, progress, and data-driven recommendations to executive leadership.
• Perform other duties as assigned.

Benefits

• Comprehensive medical, dental, vision, life, and disability plans for eligible employees and their dependents.
• Free testing for employees and their immediate families.
• Fertility care benefits.
• Pregnancy and baby bonding leave.
• 401(k) benefits.
• Commuter benefits.
• Employee referral program.

What This Job Offers

• Job Type: Full-time
• Career Level: Director