Asset Lead Medical Director - Obesity and Related Conditions

Amgen • Thousand Oaks, CA

8d • $217,673 - $294,499

About The Position

The Asset Lead Medical Director will lead development and delivery of U.S. Cardiovascular & Metabolic (CVM) Medical strategy for maridebart cafraglutide (MariTide), an investigational therapy being studied for obesity and obesity-related conditions. The role will establish the cross-indication scientific, evidence, stakeholder, and implementation foundation to support chronic weight management (CWM) launch readiness and prepare the organization for maturation in CVM. In partnership with the U.S. Medical Portfolio Lead, TA Head, Global Medical, and cross-functional colleagues, the role will translate global strategy into an integrated U.S. Medical plan.

The position will work across medical strategy, evidence generation, stakeholder engagement, scientific communications, clinical trial support, launch readiness, and governance. It will also ensure Medical activities comply with applicable laws, regulations, policies, and standard operating procedures, and use planning and performance-management processes to track progress, identify risks, and improve execution.

Requirements

• Doctorate degree and 4 years of Medical Affairs, clinical research, or cardiometabolic science research experience; or master’s degree and 7 years of such experience; or bachelor’s degree and 9 years of such experience.
• Strong clinical and scientific knowledge of cardiometabolic disease, including obesity and related conditions.
• Experience in U.S. Medical Affairs within the biopharmaceutical industry, including scientific engagement with relevant clinicians, health systems, and/or payers.
• Experience developing or implementing medical strategy, evidence-generation plans, RWE, HEOR, or access-and-use evidence in a matrixed organization.
• Knowledge of pharmaceutical product development, lifecycle planning, launch readiness, and collaboration across Clinical Operations, Commercial, Regulatory, Market Access, and Medical Affairs.
• Experience engaging external experts, professional societies, advocacy organizations, health systems, and payers for scientific exchange and insight generation.
• Ability to integrate multiple indications, scientific narratives, and stakeholder needs into a clear U.S. Medical strategy.
• Familiarity with global regulatory organizations, guidelines, and practices, including Good Clinical Practice requirements.
• Sound judgment, strong communication skills, and a track record of solving complex cross-functional problems.
• Demonstrated success leading through influence and working across matrixed, cross-functional teams.

Nice To Haves

• PharmD, PhD, MD, or another advanced scientific or clinical degree with experience in cardiometabolic disease, obesity, cardiovascular disease, heart failure, or related conditions.

Responsibilities

• Lead U.S. CVM Medical strategy, initially emphasizing CWM launch support and early cardiovascular readiness.
• Build an integrated, evidence-based CVM narrative linking obesity and the broader care continuum.
• Define U.S. scientific evidence gaps and shape local evidence, real-world evidence (RWE), health economics and outcomes research (HEOR), and Access and Use Evidence Generation priorities in alignment with global plans.
• Synthesize customer, field, market, and medical insights to inform U.S. Medical, Brand, evidence, and implementation decisions.
• Develop an early external-engagement plan for cardiologists, heart failure specialists, integrated delivery networks, professional societies, payers, and other priority stakeholders.
• Partner with Global Medical, Global Development, CfOR, HEOR, Medical Value and Access, and Scientific Communications to translate emerging evidence into U.S. strategy and execution.
• Lead or support U.S. scientific communications, including the scientific platform, core content, publication implementation, congress plans, and medical education.
• Support clinical trial activities and data interpretation as a U.S. Medical interface with Global Clinical Development and evidence-generation teams.
• Lead or support advisory boards, expert panels, and implementation-science initiatives to clarify real-world care pathways, referral patterns, and barriers to appropriate care.
• Provide medical input into reimbursement, policy, regulatory, label, and promotional-material discussions consistent with governance and evidence.
• Represent Medical in leadership, governance, launch-readiness, and cross-functional teams; recommend priorities and resource trade-offs for the U.S. Medical plan.
• Contribute to medical training and field scientific readiness for CWM/OSA and evolving CVM evidence needs.
• Support decisions on independent medical education, medical grants, sponsorships, and advocacy activities in accordance with Amgen governance.
• Ensure Medical activities comply with applicable laws, regulations, policies, and standard operating procedures.
• Use established planning and performance-management processes to measure progress, identify risks, and improve execution.

Benefits

• Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions.
• Group medical, dental, and vision coverage.
• Life and disability insurance.
• Flexible spending accounts.
• Discretionary annual bonus program, or a sales-based incentive plan for field sales representatives.
• Stock-based long-term incentives.
• Award-winning time-off plans.
• Flexible work models where possible.
• Career development opportunities.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior