Application Scientist - LC-MS
About The Position
Advion Inc. is seeking a full-time LC-MS Application Scientist to support application development, customer demonstrations, technical training, troubleshooting, and sales support for Advion's compact mass spectrometry product line, including the expression® CMS and the ASAP®, Plate Express™, and OPSI direct sampling platforms. This role focuses on ESI- and APCI-based LC-MS applications, including method development, customer sample analysis, source optimization, data interpretation, and preparation of technical application materials. The ideal candidate will have hands-on LC-MS experience, strong HPLC/UHPLC method development skills, and the ability to communicate technical information clearly to customers and internal teams.
Requirements
- Bachelor's degree or higher in Chemistry, Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a related field.
- Hands-on experience with LC-MS using ESI and/or APCI.
- Hands-on experience in HPLC/UHPLC and LC-MS method development, including assay development, LC-MS-compatible mobile phase selection, and application to small molecules, peptides, proteins, or related analyte classes.
- Practical knowledge of source setup, tuning, optimization, and troubleshooting.
- Ability to interpret mass spectra, chromatograms, and method performance data.
- Strong technical writing and communication skills.
- Ability to work independently and manage multiple application projects.
Responsibilities
- Develop, optimize, and document LC-MS methods using ESI and APCI ionization on Advion compact mass spectrometers.
- Support applications for small molecules, APIs, impurities, reaction monitoring, natural products, environmental contaminants, food safety targets, and related compounds.
- Optimize LC-MS conditions, including ion mode, source parameters, mobile phase, additives, gradient, flow rate, and sample preparation.
- Develop and demonstrate workflows for direct ionization platforms such as ASAP®, Plate Express™, and OPSI where applicable.
- Generate high-quality chromatograms, mass spectra, extracted ion chromatograms, calibration data, and method summaries.
- Analyze customer samples and perform LC-MS demonstrations to support sales opportunities.
- Troubleshoot LC-MS issues related to chromatography, source performance, sensitivity, contamination, carryover, matrix effects, and reproducibility.
- Prepare application notes, demo reports, SOPs, training materials, posters, presentations, and customer-facing technical documents.
- Work closely with sales, service, R&D, product management, and marketing teams to support customers and identify new application opportunities.
Benefits
- Generous paid time off
- 9 paid holidays
- Flexible "X" days
- 401(k) plan with company matching
- Life and disability insurance
- Access to an Employee Assistance Program
- Medical coverage through Excellus BCBS Bronze 5 high-deductible plan
- Health Reimbursement Arrangement (HRA) to offset out-of-pocket costs
- Dental
- Vision
- Flexible spending accounts
- Family leave benefits
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
