Vice President, FP&A & Financial Transformation

insitro•South San Francisco, CA

3d•$300,000 - $345,000•Hybrid

About The Position

insitro is seeking a senior finance leader to build and run its FP&A function and advance the company’s AI-enabled finance capabilities. The role will lead a transition from a bi-annual budget to a rolling quarterly forecast, establish routine scenario planning, expand self-service FP&A, and strengthen the integration of planning, close, and reporting with Accounting. The position owns the company-wide budget and forecast, headcount and compensation model, and financial materials for the Executive Team and Board. The role partners with Research, Platform, Clinical Development, People, and G&A; works closely with Accounting leadership; and coordinates with Investor Relations, Corporate Strategic Finance, and Corporate Development to align internal plans with external financial narratives. The position is based in South San Francisco, reports to the CFO, leads the FP&A team, and follows an in-person hybrid schedule averaging three days per week. The VP will oversee planning cycles, forecasting and scenario analysis; lead the finance systems roadmap and scale AI-enabled FP&A; support business and Accounting partners with cost, headcount, portfolio, and close-cycle planning; and lead the team and financial reporting to executives, the Board, and Audit Committee. The role requires extensive biotech or life sciences finance experience, public-company and Board experience, clinical development finance knowledge, systems expertise, and a track record of leading teams and scaling AI-enabled finance capabilities.

Requirements

12 or more years of FP&A or finance experience in biotech or life sciences, including ownership of a full planning cycle end to end.
Bachelor’s degree in Business, Finance, Accounting, or a related field.
Track record of building an FP&A function, including standing up a planning system, moving to a rolling forecast, and automating reporting.
Experience presenting at the Board and Audit Committee level.
Public-company experience with SEC reporting cycles and guidance-setting.
IPO preparation experience and working knowledge of public-company planning and reporting discipline.
Clinical development finance experience, including trial cost modeling, CRO/vendor management, and accruals.
Working knowledge of R&D accounting judgments that shape forecasts, such as ASC 730 and ASC 808.
Hands-on experience with an enterprise planning platform.
Strong knowledge of Oracle Cloud ERP/EPM or an equivalent system.
Strong modeling and presentation skills in Excel, think-cell, and Google Workspace.
Track record of scaling AI/LLM-enabled capability across a finance team beyond personal use.
Experience leading finance teams, including managing senior individual contributors.
Ability to build credibility with technical leaders who do not think in financial terms, prioritize and advance multiple projects under constraints, engage respectfully, and take ownership of problems and lasting solutions.

Nice To Haves

MBA, CFA, or CPA.
Consulting background.

Responsibilities

Run the planning calendar end to end, including the annual operating plan, quarterly reforecasts, and long-range plan.
Lead the shift from a bi-annual budget to a rolling quarterly forecast.
Build the annual budget across Research, Platform and Compute, Clinical Development, lab operations, and G&A.
Establish scenario planning as a standing capability and quantify the budget impact of decisions before commitments are made.
Own the finance systems roadmap for planning and analysis, including the configuration and use of Oracle Cloud ERP, integration of LLM-based tools, and potential onboarding of an FP&A solution.
Use LLM-based tools directly and develop effective individual practices into durable, team-wide capability.
Automate management packages, scorecards, and variance reports, and partner with IT and Accounting to integrate Oracle, the data warehouse, and AI tooling.
Provide cost center managers and project leads with dashboards and data access for self-service decision-making.
Translate Research, Platform, and clinical plans into cost, headcount, and timeline models, including trial costs, CRO/CMO spend, cloud and GPU commitments, and build-versus-buy decisions.
Provide program-level cost visibility for portfolio decisions, including insitro Decision Boards, and partner with People on requisition sequencing and headcount governance.
Co-own the data model, chart of accounts governance, controls alignment, and close-cycle responsibilities with Accounting leadership.
Lead and grow the FP&A team and advise the CFO on finance organization design and future hiring.
Own financial materials for the Executive Team and Board, and present budget, forecast, and variance drivers to the Board and Audit Committee.
Partner with Investor Relations, Corporate Strategic Finance, and Corporate Development to align the operating plan, guidance, capital allocation, and deal modeling.

Benefits

Annual Performance Bonus Plan, based on role-level company targets and annual company performance.
Equity Incentive Plan, subject to plan terms and associated policies.
401(k) plan with employer matching for contributions.
Medical, dental, and vision coverage, plus mental health and well-being support.
Open, flexible vacation policy.
Paid parental leave of at least 16 weeks for parents who give birth and 10 weeks for a new parent, including adoption and fostering.
Quarterly budget for books and online courses for self-development.
New-hire stipend for home office setup.
Monthly cell phone and internet stipend.
Access to free onsite baristas and daily lunch for onsite or hybrid employees.
Access to a free commuter bus network to and from the South San Francisco headquarters.