Vice President, Enterprise Technology

Avalo Therapeutics•Chesterbrook, PA

3h•Onsite

About The Position

Avalo Therapeutics is a publicly traded, clinical-stage biotechnology company advancing abdakibart into Phase 3. As Avalo prepares for late-stage development and potential commercialization, the Vice President, Enterprise Technology will build and lead a secure, validated, inspection-ready technology platform that can scale with the company and support its distributed workforce. This is a builder role combining strategic vision with hands-on execution. The position owns core infrastructure, enterprise business systems—including clinical and quality platforms—cloud operations, cybersecurity, enterprise architecture, and the technology and governance foundation for data, analytics, AI, and automation. The role requires the rigor expected of a public company in a regulated industry, including GxP, SOX, and SEC cybersecurity expectations. The Vice President will develop the technology roadmap and integrated architecture, support clinical, quality, regulatory, finance, and corporate systems, and lead cybersecurity, data governance, and responsible AI and automation governance. The role also owns technology budgeting, vendors, and team development, while promoting a service-oriented culture focused on employee experience and continuous improvement. The position requires onsite work at least three days per week, availability for urgent issues outside standard business hours as needed, and travel as required.

Requirements

Bachelor's degree in computer science, information technology, engineering, or a related field, or equivalent experience.
15 or more years of experience in IT, enterprise technology, or software engineering, including 7 or more years in senior leadership at Director level or above.
Experience in biotech, pharma, life sciences, or another highly regulated industry, such as fintech or financial services.
Track record of leading enterprise transformation in a scaling organization, including ERP, cloud, and systems integration.
Hands-on leadership of a cybersecurity program using recognized frameworks such as NIST CSF, ISO 27001, or SOC 2.
Working knowledge of GxP, 21 CFR Part 11, computer system validation, and SOX IT general controls.
Experience enabling enterprise AI, automation, advanced analytics, or modern data capabilities within a secure and governed technology environment.
Deep familiarity with cloud architecture, API-first integration, and modern data platforms.
Comfort creating structure and scaling it with discipline.
Ability to translate technology into business outcomes and communicate credibly with executives and the board.
Ability to establish practical guardrails that enable AI, automation, and analytics to scale while protecting data, compliance, and inspection readiness.
Ability to attract and develop strong people and build a team culture of ownership.
Strong written and verbal communication skills, including communicating complex technology and risk topics to non-technical audiences.
Demonstrated vendor governance, budget ownership, procurement discipline, and contract negotiation skills.
Ability to lead through influence across distributed teams, external partners, and executive stakeholders.
Onsite at least three days per week.
Availability to respond to urgent business or system issues outside standard business hours as needed.
Travel may be required to meet external partners, vendors, and auditors, and/or attend industry events.

Nice To Haves

Advanced degree.
Public company reporting experience.
Senior management and board-level engagement experience.
Experience with a Phase 2 to Phase 3 transition.
NDA/BLA submission or commercial launch readiness experience.
Experience building functions in a high-growth company.
Certifications such as CISSP, CISM, or relevant cloud certifications.
Professional network in the Greater Philadelphia life sciences community.

Responsibilities

Build and execute a multi-year enterprise technology roadmap aligned with Phase 3 execution, pipeline expansion, and commercial readiness.
Design a scalable, integrated architecture connecting corporate, clinical, quality, and finance systems.
Partner with the Senior Leadership Team to translate business priorities into technology investments with clear KPIs.
Own enterprise applications, including Veeva-based Controlled Content and Quality Management systems, ERP, HR, FP&A and accounting software, procurement, and collaboration tools.
Partner with Clinical Operations, Quality, and Regulatory on platforms such as CTMS, eTMF, EDC integrations, QMS, and RIM.
Partner with QA to lead computer system validation and ensure compliance with GxP and 21 CFR Part 11.
Maintain SOX IT general controls in partnership with Finance and external auditors.
Lead the enterprise cybersecurity program, including identity and access, endpoint security, zero trust, incident response, and third-party risk.
Provide cybersecurity reporting to senior management and the Audit Committee and support SEC cybersecurity disclosure requirements.
Protect clinical trial data, intellectual property, and personal data under PIP, GDPR, and state privacy laws.
Ensure high availability and reliability across cloud, network, and endpoint environments for a distributed workforce.
Oversee secure data exchange with CROs, CDMOs, and other external partners.
Establish and maintain enterprise data architecture, platforms, integration standards, and technology controls to support data governance, analytics, and AI capabilities.
Establish and oversee the enterprise technology, security, and governance framework for responsible adoption of AI, automation, and advanced analytics.
Partner with the Senior Director, AI & Data Transformation on a shared approval model for AI initiatives, addressing business value, adoption, architecture, security, privacy, integration, validation, and deployment readiness.
Own the technology budget, including capital and operating expense planning, forecasting, licensing, vendor selection, and managed service provider performance.
Hire, develop, and scale a high-performing team across IT operations, business systems, and security.
Promote a service-oriented culture focused on employee experience, enablement, and continuous improvement.