Technical Officer, Downstream Processing
About The Position
The NRC is Canada's largest research and innovation organization, pushing the boundaries of science and engineering. The Human Health Therapeutics Research Center (HHT) supports healthcare innovations and has a strong track record of collaborations with industry, particularly with Canadian SMEs developing therapeutic products, biologics, or vaccines. The Technical Officer will support the Downstream Processing team in developing robust and scalable purification processes for biologics manufacturing. This role involves supporting early-stage programs, drug development through process optimization, and clinical trial programs by providing technical support for cGMP clinical batch manufacturing. The position requires rigorous documentation, adherence to procedures, and collaboration with process development and manufacturing teams.
Requirements
- Bachelor of Science degree (B.Sc.) in biotechnology, biochemistry or a field related to the position.
- Significant experience operating ÄKTA chromatography systems and developing methods using Unicorn software.
- Significant experience in chromatography column packing.
- Significant experience in buffer preparation and handling of large liquid volumes.
- Significant experience in aseptic liquid handling techniques.
- Significant experience in setting up and operating tangential flow filtration systems, depth filtration, nanofiltration, and sterile filtration.
- Significant experience in drafting and revising standard operating procedures and batch records.
- Significant experience in data analysis with MS Excel or similar software packages.
- Experience in biologics manufacturing under GMP environment.
- Reliability Status
Nice To Haves
- A Master’s graduate degree (M.Sc.) in biotechnology, biochemistry or a field related to the position would be considered an asset.
- Experience with a range of DNA and protein analytical techniques, including ELISA, UPLC, and dPCR, will be considered an asset.
Responsibilities
- Adapt and execute platform purification processes in low- or high-throughput formats to achieve target yield and purity of drug candidates.
- Pack and qualify chromatography columns for lab- to large-scale processes and maintain associated column hardware.
- Prepare buffers for small- and large-scale processing in both R&D and GMP environments using scale-appropriate equipment.
- Execute DSP development studies using a QbD approach; demonstrate process robustness and scalability (including impurity/residual clearance and intermediate stability); and scale up processes from bench to pilot scale for GMP manufacturing transfer.
- Provide technical support and assist in cGMP clinical batch manufacturing at CTMF.
- Write batch records and standard operating procedures; maintain detailed records of experimental design, results, and procedures per internal quality standards and regulatory expectations.
- Coordinate procurement of DSP consumables and ensure timely availability to meet project timelines.
- Adhere to occupational health and safety protocols, laboratory security measures, and research confidentiality requirements.
Benefits
- Robust pension plan
- Comprehensive health and dental coverage
- Disability and life insurance
- Office closure at the end of December
- Additional supports to enhance your well-being throughout your career and beyond.
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
