Structural Biology Research Scientist

Guidehouse•Bethesda, MD

1d•$85,000 - $141,000•Onsite

About The Position

We are seeking a Structural Biology Research Scientist to support the National Institute of Allergy and Infectious Diseases (NIAID) through viral protein construct design, expression optimization, protein purification, and cryo-electron microscopy studies that advance vaccine development. Ideal candidates will bring structural virology experience and skills in assay development, data analysis, reporting, and mentorship. This is a full-time, on-site opportunity in Bethesda, MD.

Requirements

PhD in Structural Biology or a related field
Microsoft Office
Technical experience needed to assist in studying the basic principles of plant and animal life.
Technical support and troubleshooting of sophisticated equipment.
At least 2 (two) years of experience
Must be able to obtain and maintain a Federal or DoD "public trust"; candidates must obtain approved adjudication of their public trust prior to onboarding with Guidehouse.

Nice To Haves

Structural virology experience
Skills in assay development, data analysis, reporting, and mentorship.
Candidates with an active public trust or suitability are preferred
Previous experience supporting NIH

Responsibilities

Design and generate expression constructs for viral proteins (e.g., envelope glycoproteins, capsid proteins, regulatory proteins).
Develop and optimize expression systems (mammalian, insect, or stable cell lines).
Purify proteins using chromatography methods (affinity, SEC, ion exchange).
Perform binding and antigenicity assays (e.g., ELISA, BLI, SPR)
Conduct biochemical and biophysical characterization (e.g., SEC-MALS, DLS)
Prepare samples and optimize vitrification conditions for cryo-EM studies
Operate and/or coordinate use of cryo-EM instruments (e.g., Titan Krios, Glacios)
Prepare technical reports, figures, and manuscripts

Benefits

Medical, Rx, Dental & Vision Insurance
Personal and Family Sick Time & Company Paid Holidays
Parental Leave
401(k) Retirement Plan
Group Term Life and Travel Assistance
Voluntary Life and AD&D Insurance
Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts
Transit and Parking Commuter Benefits
Short-Term & Long-Term Disability
Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities
Employee Referral Program
Corporate Sponsored Events & Community Outreach
Care.com annual membership
Employee Assistance Program
Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)
Position may be eligible for a discretionary variable incentive bonus