Post Doc Scientist, Structural Biology and Chemistry

Gilead Sciences • Foster City, CA

9d

About The Position

At Gilead, our pursuit of a healthier world for all people has yielded a cure for hepatitis C, revolutionary improvements in HIV treatment and prevention, as well as advancements in therapies for viral and inflammatory diseases and certain cancers. We set and achieve bold ambitions in our fight against the world’s most devastating diseases, united in our commitment to confronting the largest public health challenges of our day and improving the lives of patients for generations to come. As a Postdoctoral Scientist at Gilead, you will support the Structural Biology and Chemistry department, working on AI/ML for Small Molecule Drug Discovery. A highly motivated, attentive, and self-driven postdoctoral researcher candidate will join the Computational Modeling Group as part of a three-year postdoctoral training program. The successful candidate will work at the forefront of innovation by utilizing cutting-edge AI/ML-based technologies. This is a three-year fixed-term postdoctoral position.

Requirements

• Ph.D. and 0+ years of relevant research experience with deep expertise in AI/ML as applied to drug discovery and/or in Computational Chemistry.
• Knowledge of machine learning architectures relevant to chemistry and structural biology.
• Strong programming skills in Python and proficiency with ML frameworks.
• Ability to design, implement and evaluate robust model validation strategies, including uncertainty quantification and applicability domain assessment.
• Excellent communication skills (both verbal and technical) and interpersonal skills.
• Must think critically and creatively and be able to work independently, determine appropriate resources for resolution of problems and have strong organizational and planning skills.

Nice To Haves

• Expertise with cheminformatics toolkits such as RDKit, OpenEye or Schrodinger desired.

Responsibilities

• Detailed evaluation and analysis of AI tools and ML models which can be impactful for various stages of Small Molecule Drug Discovery, from hit identification through hit-to-lead to lead optimization.
• Clearly communicate these findings via internal Gilead and external presentations, as well as through publishing in high-impact journals.
• Utilizing the rich set of historical Gilead data and structures, evaluate co-folding tools, potency models and ADME models in partnership with other Computational Chemists and AI/ML Scientists.
• Implement and analyze methods used to enable virtual screening of ultra-large libraries, including but not limited to Active Learning and Thompson Sampling.
• Investigate the feasibility of utilizing machine learning models to predict properties of heterobifunctional degraders (EPSA, permeability, etc.) using either SMILES strings or three-dimensional conformational ensembles as starting points.

Benefits

• Equal employment opportunities
• Fostering an inclusive work environment comprised of diverse perspectives, backgrounds, and experiences
• Employment decisions regarding recruitment and selection will be made without discrimination
• Reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990
• Know Your Rights poster
• Employee Polygraph Protection Act
• Rights Under the Family and Medical Leave Act
• Will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant
• Respects individual differences and recognizes each employee as an integral member of our company
• Workforce reflects these values and celebrates the individuals who make up our growing team
• Work environment free of harassment and prohibited conduct
• Promote and support individual differences and diversity of thoughts and opinion

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree