Immunology - Staff Scientist

LLNL•Livermore, CA

19h•Onsite

About The Position

We are seeking a staff scientist with expertise in next generation sequencing (NGS) and animal models of infection and disease to conduct independent research aimed at understanding immunological mechanisms relevant to preventative countermeasure strategies for future pandemics and emerging biothreats. The successful applicants will contribute advanced technical expertise to the development of a host-response research pipeline for characterizing immune responses induced by infection, vaccination or environmental exposures and for evaluating biologic countermeasures. The position is in the Translational Immunology group within the Biosciences and Biotechnology Division.

Requirements

Ability to secure and maintain a U.S. DOE Q-level security clearance which requires U.S. citizenship
PhD in Immunology, molecular biology, infectious disease, or a relevant field.
Significant experience designing, implementing and validating NGS workflows for applications in understanding immune responses in vivo.
Working knowledge of multi-color flow cytometry and immunohistochemistry assays.
Significant experience troubleshooting complex molecular workflows and implementing quality control strategies.
Experience working with rodent animal models, including handling and drug or vaccine administration,
Ability to work with a high level of independence as demonstrated through publication of peer-reviewed literature.
Significant experience designing and executing independent research studies
Advanced verbal and written communication and interpersonal skills necessary to collaborate effectively in a multidisciplinary team environment, present technical information and provide technical guidance.

Nice To Haves

Experience designing, implementing, and analyzing multi-color flow cytometry and cell sorting experiments.
Experience with 3D ex vivo cultures and/or organoids.
Working knowledge of applications for accelerator mass spectrometry (AMS).

Responsibilities

Conduct independent research in biological exposure (pathogen/environmental) and its impact on immunology and disease.
Conceive, develop, and implement experimental approaches related to pathogen exposures and the immune effects based on immunological and biochemical characterization of cells, transcripts, proteins and metabolites.
Conduct studies to support the discovery, validation, and mechanistic understanding of signaling pathways that can be further translated into new treatments for a variety of diseases or infections.
Collaborate with interdisciplinary team of scientists, project leaders and program leaders, and external partners to achieve research objectives
Publish research results in peer-reviewed scientific or technical journals and present results at external conferences, seminars, and/or technical meetings.
Prepare technical reports and present research findings to internal and external audiences.
Perform other duties as assigned.